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Titolo:
Microvascular dysfunction in acute myocardial infarction: Focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon
Autore:
Michaels, AD; Gibson, CM; Barron, HV;
Indirizzi:
Univ Calif San Francisco, Med Ctr, Dept Med, Div Cardiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Genentech Inc, S San Francisco, CA 94080 USA Genentech Inc S San Francisco CA USA 94080 S San Francisco, CA 94080 USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 5A, volume: 85, anno: 2000,
pagine: 50B - 60B
SICI:
0002-9149(20000309)85:5A<50B:MDIAMI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; LEFT-VENTRICULAR FUNCTION; ATTENUATES NEUTROPHIL ACCUMULATION; INTERCELLULAR-ADHESION MOLECULE-1; TISSUE-PLASMINOGEN-ACTIVATOR; ISCHEMIC-HEART-DISEASE; 12-MONTH FOLLOW-UP; BLOOD-CELL COUNT; REPERFUSION INJURY; CORONARY ANGIOPLASTY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
141
Recensione:
Indirizzi per estratti:
Indirizzo: Michaels, AD Univ Calif San Francisco, Med Ctr, Dept Med, Div Cardiol, 505Parnassus Ave,Box 0124, San Francisco, CA 94143 USA Univ Calif San Francisco 505 Parnassus Ave,Box 0124 San Francisco CA USA 94143
Citazione:
A.D. Michaels et al., "Microvascular dysfunction in acute myocardial infarction: Focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon", AM J CARD, 85(5A), 2000, pp. 50B-60B

Abstract

Recent interest has shifted from infarct artery potency to microvascular perfusion in the evaluation of: patients with acute myocardial infarction (AMI). Microvascular dysfunction occurs in a substantial proportion of patients, despite aggressive therapy with thrombolytic agents and/or percutaneousmechanical revascularization techniques. Patients with impaired microvascular perfusion after immediate reperfusion therapy have an adverse clinical prognosis. Recent studies have extended our understanding of the pathophysiology of this so-called no-reflow phenomenon, focusing on the critical roles of platelet and inflammatory mediators leading to microvascular obstruction and reperfusion injury. Moving beyond the Thrombolysis in Myocardial Infarction (TIMI) flow grade system, new techniques have been developed to assess microvascular perfusion, including TIMI frame counting, angiographic myocardial perfusion grading, myocardial contrast echocardiography, Doppler flow wire studies, nuclear scintigraphy, and magnetic resonance imaging. Armed with a greater understanding of the primary mediators of microvascular dysfunction, these fools may identify improved therapy directed at optimizing myocardial perfusion in patients with AMI. (C)2000 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 11:02:03