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Titolo:
In vivo monitoring of drugs using radiotracer techniques
Autore:
Saleem, A; Aboagye, EO; Price, PM;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med,MRCCyclotron Unit, CRC PET Oncol Grp,Sect Canc Therapeut, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 1, volume: 41, anno: 2000,
pagine: 21 - 39
SICI:
0169-409X(20000315)41:1<21:IVMODU>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; D2-DOPAMINE RECEPTOR OCCUPANCY; MAGNETIC-RESONANCE SPECTROSCOPY; ENZYME PRODRUG THERAPY; MYOCARDIAL BLOOD-FLOW; CELL LUNG-CARCINOMA; BREAST-CANCER; P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; COLORECTAL-CARCINOMA;
Keywords:
PET; SPECT; pharmacokinetics; pharmacodynamics; drug receptor interaction; drug resistance; 5-fluorouracil;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
135
Recensione:
Indirizzi per estratti:
Indirizzo: Saleem, A Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med,MRCCyclotron Unit, CRC PET Oncol Grp,Sect Canc Therapeut, Du Cane Rd, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med Du Cane Rd London England W12 0NN
Citazione:
A. Saleem et al., "In vivo monitoring of drugs using radiotracer techniques", ADV DRUG DE, 41(1), 2000, pp. 21-39

Abstract

There is an increasing realization of the role of non-invasive monitoring of drug pharmacology. In this review, we discuss the role of positron emission tomography in such monitoring of tumour and normal tissue drug pharmacokinetics as well as assessment of tumour response, drug-receptor interactions and mechanisms of drug action and resistance. These studies represent a multidisciplinary research effort involving radiochemists, imaging scientists, clinicians, pharmacologists and mathematical modellers. This review evaluates achievements in the field from assessment of commonly used therapeutic agents such as 5-fluorouracil to target specific molecules such as markers for gene expression. It is envisaged that application of this technologywill facilitate rational drug design and rapid translation of new ideas tothe bedside. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:23:42