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Titolo:
Hippocampal and temporal lobe atrophy and age-related decline in memory
Autore:
Ylikoski, R; Salonen, O; Mantyla, R; Ylikoski, A; Keskivaara, P; Leskela, M; Erkinjuntti, T;
Indirizzi:
Helsinki Univ Hosp, Memory Res Unit, Helsinki, Finland Helsinki Univ HospHelsinki Finland Memory Res Unit, Helsinki, Finland Helsinki Univ Hosp, Dept Radiol, Helsinki, Finland Helsinki Univ Hosp Helsinki Finland osp, Dept Radiol, Helsinki, Finland Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland Univ Helsinki Helsinki Finland SF-00100 chol, SF-00100 Helsinki, Finland Helsinki Univ Hosp, Dept Clin Neurosci, Neuropsychol Unit, FIN-00029 Helsinki, Finland Helsinki Univ Hosp Helsinki Finland FIN-00029 IN-00029 Helsinki, Finland
Titolo Testata:
ACTA NEUROLOGICA SCANDINAVICA
fascicolo: 4, volume: 101, anno: 2000,
pagine: 273 - 278
SICI:
0001-6314(200004)101:4<273:HATLAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROBABLE ALZHEIMERS-DISEASE; VISUAL MEMORY; VERBAL MEMORY; MRI; IMPAIRMENT; INDIVIDUALS; REDUCTIONS; FRAMINGHAM; COHORT; MATTER;
Keywords:
memory; hippocampus; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ylikoski, R Helsinki Univ Hosp, Dept Clin Neurosci, Neuropsychol Unit, POB300, FIN-00029 Helsinki, Finland Helsinki Univ Hosp POB 300 Helsinki Finland FIN-00029 Finland
Citazione:
R. Ylikoski et al., "Hippocampal and temporal lobe atrophy and age-related decline in memory", ACT NEUR SC, 101(4), 2000, pp. 273-278

Abstract

(C) Munksgaard 2000. Objectives - To evaluate the relationship of memory decline that accompanies aging with structural changes in the medial temporal lobe, in healthy middle-aged and older subjects. Material and methods - Asample of 35 neurologically non-diseased subjects, between 55 and 70 yearsof age, were examined in a 5-year follow-up study. Neuropsychological investigation included tests of learning, verbal memory, and visual memory. MRIwas performed with a superconducting MRI system operating at 1.0 T, using coronal slices of T1-weighted images. Medial temporal lobe atrophy was rated separately in the neocortical, entorhinal and hippocampal regions. Results - We did not find any statistically significant relationship between mildhippocampal or temporal atrophy and memory test performance. Nor did the longitudinal decline in memory show a relationship with temporal lobe atrophy. Conclusions - The main outcome of our study was that age-related memory decline was not related to mild temporal lobe atrophy in healthy subjects without mild cognitive impairment. There could be other factors influencing memory functions besides age-related structural changes in temporal lobes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:45:23