Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tissue plasminogen activator and plasminogen activator inhibitor-1 in human choledochal bile
Autore:
Lee, SJ; Cho, JS; Chung, JP; Lee, KS; Chung, JB; Lee, SI; Moon, YM; Kang, JK; Kwon, SW; Chi, HS; Choi, JR; Song, KS;
Indirizzi:
Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea Yonsei Univ Seoul South Korea ed, Dept Internal Med, Seoul, South Korea Yonsei Univ, Coll Med, Dept Gen Surg, Seoul, South Korea Yonsei Univ Seoul South Korea ll Med, Dept Gen Surg, Seoul, South Korea Yonsei Univ, Coll Med, Dept Clin Pathol, Seoul, South Korea Yonsei Univ Seoul South Korea Med, Dept Clin Pathol, Seoul, South Korea
Titolo Testata:
YONSEI MEDICAL JOURNAL
fascicolo: 1, volume: 41, anno: 2000,
pagine: 119 - 122
SICI:
0513-5796(200002)41:1<119:TPAAPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED IMMUNOSORBENT-ASSAY; FIBRINOLYSIS; BILOKINASE; PREGNANCY;
Keywords:
fibrinolysis; biliary tract; choledocholithiasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SJ Yonsei Univ, Coll Med, Dept Internal Med, Yongdong Severance Hosp,POB 1217, Seoul 135270, South Korea Yonsei Univ POB 1217 Seoul South Korea 135270 135270, South Korea
Citazione:
S.J. Lee et al., "Tissue plasminogen activator and plasminogen activator inhibitor-1 in human choledochal bile", YONSEI MED, 41(1), 2000, pp. 119-122

Abstract

Fibrinolytic properties have been detected in animal and human gallbladder(GB) bile. Plasminogen activator inhibitor-1 (PAI-1) has been reported in greater concentration in GB stone bile and may be a nucleating factor in the pathogenesis of GB stone formation. it is unknown whether or not human choledochal bile has similar properties, which could have a role in choledocholithiasis. The aims of this study were to determine the presence of fibrinolytic properties of human choledochal bite and to compare those propertiesamong normal, acalculous, and calculous-infected choledochal bile. Tissue plasminogen activator (t-PA) and PAI-1 of choledochal bile were measured byenzyme linked immunosorbent assay in patients with cholangitis due to acalculous bile duct obstructions (n=9), choledocholithiasis with cholangitis (n=20), and normal bile (n=7). The t-PA concentration of choledochal bile was no different among the three groups (acalculous-infected bile, median 4.61 ng/ml, and calculous-infected bile, 4.61 ng/ml, versus normal bile, 7.33 ng/ml). PAI-1 was detected in choledochal bile in significantly greater concentrations in patients with acalculous cholangitis due to bile duct obstructions and choledocholithiasis with cholangitis (acalculous-infected bile, median 0.36 ng/ml, and calculous-infected bile, 0.1 ng/ml, versus normal bile, 0.02 ng/ml, p<0.05), but the bile concentration of PAI-1 was no different between the acalculous and calculous-infected choledochal bile. Human choledochal bile possesses t-PA and PAI-1. PAI-1 was present in greater concentrations in both acalculous and calculous-infected choledochal bile. Increased levels of PAI-1 may be an epiphenomenon of cholangitis rather than a factor in the pathogenesis of choledocholithiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:31:10