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Titolo:
Genetic organisation of the capsule biosynthetic locus of Pasteurella multocida M1404 (B : 2)
Autore:
Boyce, JD; Chung, JY; Adler, B;
Indirizzi:
Monash Univ, Dept Microbiol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 biol, Clayton, Vic 3168, Australia
Titolo Testata:
VETERINARY MICROBIOLOGY
fascicolo: 1-2, volume: 72, anno: 2000,
pagine: 121 - 134
SICI:
0378-1135(20000301)72:1-2<121:GOOTCB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROBACTERIAL COMMON-ANTIGEN; GRAM-NEGATIVE BACTERIA; NUCLEIC-ACID SEQUENCES; ESCHERICHIA-COLI K5; POLYSACCHARIDE EXPORT; NEISSERIA-MENINGITIDIS; MOLECULAR ANALYSIS; VIRULENCE; IDENTIFICATION; EXPRESSION;
Keywords:
Pasteurella multocida; capsule biosynthesis; haemorrhagic septicaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, B Monash Univ, Dept Microbiol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 yton, Vic 3168, Australia
Citazione:
J.D. Boyce et al., "Genetic organisation of the capsule biosynthetic locus of Pasteurella multocida M1404 (B : 2)", VET MICROB, 72(1-2), 2000, pp. 121-134

Abstract

Capsules from a range of bacterial species have been shown to be major virulence determinants and capsule has been implicated in virulence in Pasteurella multocida. Moreover, capsular serogroup appears to be related to disease predilection. Haemorrhagic septicaemia strains belong to serogroup B andE, fowl cholera strains to serogroup A and atrophic rhinitis strains to serogroup D. The entire capsule biosynthetic locus of P. multocida A:1 has been cloned and its nucleotide sequence determined (Chung et al., 1998. FEMS Microbiol. Lett. 166, 289-296); however, nothing is known of the P. multocida B:2 capsule locus. In this work we have determined the nucleotide sequence and genetic organisation of the P. multocida M1404 (B:2) capsule locus. By analogy with the cap loci of other bacteria, the nucleotide sequence canbe divided into three functional regions. Regions 1 and 3 comprise six genes involved in transport of the polysaccharide capsule to the cell surface. The deduced products of these genes show high similarity to proteins involved in capsule export in other bacteria. Region 2 comprises nine genes which are likely involved in biosynthesis of the polysaccharide capsule. The deduced products of three of these genes (bcbA, bcbB and bcbC) show significant similarity to proteins known to be involved in polysaccharide biosynthesis while the other six show no similarity to known proteins. However, theirorganisation indicates they are cotranscribed with bcbA, bcbB, bcbC and the Region 1 capsule export genes, suggesting strongly that they are also involved in capsule biosynthesis. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:17:04