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Titolo:
Cell birth, cell death, cell diversity and DNA breaks: how do they all fittogether?
Autore:
Gilmore, EC; Nowakowski, RS; Caviness, VS; Herrup, K;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Hosp Cleveland, Dept Neurol, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 eurol, Cleveland, OH 44106 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 scataway, NJ 08854 USA Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 h Med, Dept Neurol, Boston, MA 02114 USA
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 3, volume: 23, anno: 2000,
pagine: 100 - 105
SICI:
0166-2236(200003)23:3<100:CBCDCD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; SEVERE COMBINED IMMUNODEFICIENCY; MURINE CEREBRAL WALL; V(D)J RECOMBINATION; CYTOCHROME-C; LIGASE-IV; PROLIFERATIVE EPITHELIUM; APOPTOTIC PATHWAYS; IN-VIVO; REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Gilmore, EC Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 OH 44106 USA
Citazione:
E.C. Gilmore et al., "Cell birth, cell death, cell diversity and DNA breaks: how do they all fittogether?", TRENDS NEUR, 23(3), 2000, pp. 100-105

Abstract

Substantial death of migrating and differentiating neurons occurs within the developing CNS of mice that ave deficient in genes required for repair of double-stranded DNA breaks. These findings suggest that large-scale,yet previously unrecognized, double-stranded DNA breaks occur normally in early postmitotic and differentiating neurons. Moreover, they imply that cell death occurs if the breaks are not repaired,The cause and natural function of such breaks remains a mystery; however their occurrence has significant implications. They might be detected by histological methods that are sensitive to DNA fragmentation and mistakenly interpreted to indicate cell death when no relationship exists. In a broader context, there is now renewed speculation that DNA recombination might be occurring during neuronal development, similar to DNA recombination in developing lymphocytes, If this is true,the target gene(s) of recombination and their significance remain to be determined.

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Documento generato il 30/03/20 alle ore 00:23:26