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Titolo:
Structure, measurement, and secretion of human glucagon-like peptide-2
Autore:
Hartmann, B; Johnsen, AH; Orskov, C; Adelhorst, K; Thim, L; Holst, JJ;
Indirizzi:
Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen N, Denmark Univ Copenhagen Copenhagen Denmark N siol, DK-2200 Copenhagen N, Denmark Univ Copenhagen, Panum Inst, Dept Med Anat, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen 0, Denmark Rigshosp Copenhagen Denmark 0 lin Biochem, DK-2100 Copenhagen 0, Denmark Novo Nordisk AS, DK-2880 Bagsvaerd, Denmark Novo Nordisk AS Bagsvaerd Denmark DK-2880 AS, DK-2880 Bagsvaerd, Denmark
Titolo Testata:
PEPTIDES
fascicolo: 1, volume: 21, anno: 2000,
pagine: 73 - 80
SICI:
0196-9781(200001)21:1<73:SMASOH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-INHIBITORY POLYPEPTIDE; HUMAN SMALL-INTESTINE; PIG SMALL-INTESTINE; PREPROGLUCAGON GENE; IN-VIVO; PROGLUCAGON; PANCREAS; GUT; GLICENTIN; PRODUCTS;
Keywords:
proglucagon; radioimmunoassay; GLP-2; GLP-1; DPP-IV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Holst, JJ Univ Copenhagen, Panum Inst, Dept Med Physiol, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark Univ Copenhagen Blegdamsvej 3 Copenhagen Denmark N n N, Denmark
Citazione:
B. Hartmann et al., "Structure, measurement, and secretion of human glucagon-like peptide-2", PEPTIDES, 21(1), 2000, pp. 73-80

Abstract

By using radioimmunoassays toward the cDNA-predicted amino acid sequence of human glucagon-like peptide-2, a peptide was isolated from extracts of human ileum. By mass spectrometry and Edman sequencing, this peptide was identified as human proglucagon 126-158. High-performance liquid chromatographyanalyses indicated that a similar immunoreactive peptide (iGLP-2) was present in human plasma. Human plasma concentrations of iGLP-2 were elevated 3-to 4-fold at 1 to 2 h after ingestion of 800 to 1200 kcal meals. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:04:25