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Titolo:
Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris
Autore:
Koyama, K; Ito, Y;
Indirizzi:
Kitasato Univ, Sch Med, Dept Parasitol, Kanagawa 2288555, Japan Kitasato Univ Kanagawa Japan 2288555 Parasitol, Kanagawa 2288555, Japan
Titolo Testata:
PARASITE IMMUNOLOGY
fascicolo: 1, volume: 22, anno: 2000,
pagine: 13 - 20
SICI:
0141-9838(200001)22:1<13:MMCRAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATORY FACTOR-I; T-CELL; IMMUNE-RESPONSES; NIPPOSTRONGYLUS-BRASILIENSIS; LYMPHOKINE ACTIVITIES; INTESTINAL NEMATODE; LYMPHOCYTE-T; NUDE-MICE; SUBSETS; INTERLEUKIN-4;
Keywords:
Trichuris muris; nematode parasites; mucosal mast cells; W/W-v mice; +/+ mice; worm expulsion; IL-4; IFN-gamma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Koyama, K Kitasato Univ, Sch Med, Dept Parasitol, 1-15-1 Kitasato, Kanagawa 2288555,Japan Kitasato Univ 1-15-1 Kitasato Kanagawa Japan 2288555 8555,Japan
Citazione:
K. Koyama e Y. Ito, "Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris", PARASITE IM, 22(1), 2000, pp. 13-20

Abstract

The involvement of mucosal mast cells (MMC) in protection against infection with the murine nematode parasite Trichuris muris was studied in genetically mast cell-deficient WBB6F1-W/W-v mice and their normal littermates WBB6F1-+/+ mice. Expulsion of T. muris worms occurred in infected +/+ mice, whereas no worm expulsion was observed in infected W/W-v mice where the infection persisted until at least day 46 postinfection. No MMC responses were induced in either infected W/W-v or +/+ mice. Specific IgG1 and IgG2a antibodies to T. muris excretory/secretory antigens were observed in infected W/W-v and +/+ mice, and antibody production showed similar kinetics. Interleukin 4 production by concanavalin A (Con A)-stimulated mesenteric lymph node cells (MLNC) was induced preferentially in infected +/+ mice. T. muris infection increased the levels of IFN-gamma produced by Con A-stimulated MLNC ofinfected W/W-v and +/+ mice, with the levels of IFN-gamma in infected W/W-v mice being higher than those in infected +/+ mice. Taken together, these results indicate that W/W-v and +/+ mice are susceptible and resistant to T. muris infection, respectively, and that MMC responses are not required for protective immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:32:40