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Titolo:
A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland
Autore:
Schulze-Garg, C; Lohler, J; Gocht, A; Deppert, W;
Indirizzi:
Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-20251 Hamburg, Germany Univ Hamburg Hamburg Germany D-20251 & Immunol, D-20251 Hamburg, Germany Mice & More, D-20251 Hamburg, Germany Mice & More Hamburg Germany D-20251 ice & More, D-20251 Hamburg, Germany Marienkrankenhaus, Inst Pathol, D-22087 Hamburg, Germany Marienkrankenhaus Hamburg Germany D-22087 thol, D-22087 Hamburg, Germany
Titolo Testata:
ONCOGENE
fascicolo: 8, volume: 19, anno: 2000,
pagine: 1028 - 1037
SICI:
0950-9232(20000221)19:8<1028:ATMMFT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE T-ANTIGEN; BREAST-CONSERVING SURGERY; PROTEIN GENE PROMOTER; IN-SITU; INTRADUCTAL CARCINOMA; RESTRICTION ELEMENT; BALB/C MICE; HYBRID GENE; HA-RAS; EXPRESSION;
Keywords:
DCIS; ductal carcinoma in situ; mouse model; SV40 large T-antigen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Schulze-Garg, C Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, Martinistr 52, D-20251 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20251 ermany
Citazione:
C. Schulze-Garg et al., "A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland", ONCOGENE, 19(8), 2000, pp. 1028-1037

Abstract

The ductal carcinoma in situ (DCIS) of the mammary gland represents an early, pre-invasive stage in the development of invasive breast carcinoma and is increasingly diagnosed since the introduction of high-quality mammography screening. Uncertainties in the prognosis for patients with DCIS have caused a controversial discussion about adequate treatment, and it is suspected that most patients undergoing mastectomy may be overtreated, In order to improve treatment and treatment decision, it therefore is highly desirable to identify prognostic markers and therapeutic targets for DCIS. We here introduce a set of transgenic mice (WAP-T and WAP-T-NP lines) presenting withvarious morphological forms of DCLS-like lesions. In these mite the SV40 large tumor antigen is specifically induced in epithelial cells of the terminal duct lobular units (TDLU), As a consequence of continuous expression ofthe oncogene, the animals develop multifocal DCIS and consequently invasive carcinoma within strain specific periods of latency. DCIS lesions in transgenic mire exhibit distinct architectural and cytological features which closely resemble those commonly present in humans, We therefore propose these transgenic lines as an experimental model to study the underlying molecular events leading to DCIS and its progression to invasive disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:38:29