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Titolo:
Relationship between thyroglobulin and tumor detectability with thallium-201 in differentiated thyroid cancer
Autore:
Brandt-Mainz, K; Muller, SP; Reiners, C; Bockisch, A;
Indirizzi:
Univ Kliniken Essen, Nukl Med Klin & Poliklin, Essen, Germany Univ Kliniken Essen Essen Germany l Med Klin & Poliklin, Essen, Germany Univ Kliniken Wurzburg, Wurzburg, Germany Univ Kliniken Wurzburg Wurzburg Germany ken Wurzburg, Wurzburg, Germany
Titolo Testata:
NUKLEARMEDIZIN
fascicolo: 1, volume: 39, anno: 2000,
pagine: 10 - 15
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLOW-UP; SERUM THYROGLOBULIN; TL-201 SCINTIGRAPHY; I-131 THERAPY; CARCINOMA; RADIOIODINE; TECHNETIUM-99M-TETROFOSMIN; METASTASES; MANAGEMENT; SCANS;
Keywords:
thallium-201-scintigraphy; thyroglobulin; differentiated thyroid cancer; ROC-analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Brandt-Mainz, K Univ Essen Gesamthsch Klinikum, Nukl Med Klin & Poliklin, Hufelandtr 55, D-45122 Essen, Germany Univ Essen Gesamthsch Klinikum Hufelandtr 55 Essen Germany D-45122
Citazione:
K. Brandt-Mainz et al., "Relationship between thyroglobulin and tumor detectability with thallium-201 in differentiated thyroid cancer", NUKLEARMED, 39(1), 2000, pp. 10-15

Abstract

Aim: Tumor scintigraphy with 201-TlCl is on established diagnostic method in the follow-up of differentiated thyroid cancer. We investigated the relationship between thyroglobolin (Tg) level and tumor detectability. Subject and methods: We analyzed the scans of 122 patients (66 patients with proventumor). The patient population was divided into groups with Tg above (N = 33) and below (N = 33) 5 ng/ml under TSH suppression or above (N = 33) and below (N = 33) 50 ng/ml under TSH stimulation. Tumor detectability was compared by ROC-analysis (True-Positive-Fraction test, specificity 90%). Results: There was no significant difference (sensitivity 75% versus 64%; p = 0.55) for patients above and below 5 ng/ml under TSH suppression and a just significant difference (sensitivity 80% venus 58%; p = 0.04) for patients above and below 50 ng/ml under TSH stimulation. In 18 patients from our samplewith tumor, Tg under TSH suppression was negative, but 201-TlCl-scan was able to detect tumor in 12 patients. Conclusion: Our results demonstrate only a moderate dependence of tumor detectability on Tg level, probably without significant clinical relevance. Even in patients with slight Tg elevation201-TlCl scintigraphy is justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:05:04