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Titolo:
Regional brain activation by bicuculline visualized by functional magneticresonance imaging. Time-resolved assessment of bicuculline-induced changesin local cerebral blood volume using an intravascular contrast agent
Autore:
Reese, T; Bjelke, B; Porszasz, R; Baumann, D; Bochelen, D; Sauter, A; Rudin, M;
Indirizzi:
Novartis Pharma Ltd, RES CTA IVM, Core Technol Area, CH-4002 Basel, Switzerland Novartis Pharma Ltd Basel Switzerland CH-4002 CH-4002 Basel, Switzerland Karolinska Sjukhuset, MR Ctr, S-17176 Stockholm, Sweden Karolinska Sjukhuset Stockholm Sweden S-17176 S-17176 Stockholm, Sweden Novartis Pharma Ltd, Nervous Syst Therapeut Area, CH-4002 Basel, Switzerland Novartis Pharma Ltd Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 1, volume: 13, anno: 2000,
pagine: 43 - 49
SICI:
0952-3480(200001)13:1<43:RBABBV>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; FOREPAW STIMULATION; INDUCED SEIZURES; MRI; TRANSIT; SYSTEM; SIGNAL;
Keywords:
functional MRI (fMRI); pharmacological stimulation; bicuculline; intravascular contrast agent; cerebral blood volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Rudin, M Novartis Pharma Ltd, RES CTA IVM, Core Technol Area, WSJ-386-2-02, CH-4002Basel, Switzerland Novartis Pharma Ltd WSJ-386-2-02 Basel Switzerland CH-4002 rland
Citazione:
T. Reese et al., "Regional brain activation by bicuculline visualized by functional magneticresonance imaging. Time-resolved assessment of bicuculline-induced changesin local cerebral blood volume using an intravascular contrast agent", NMR BIOMED, 13(1), 2000, pp. 43-49

Abstract

Functional magnetic resonance imaging (fMRI) has been applied to study ratfocal brain activation induced by intravenous administration of the GABAA antagonist bicuculline. Using magnetite nanoparticles as a blood pool contrast agent, local changes in cerebral blood volume (CBV) were assessed with high temporal (10 s) and spatial (0.35 x 0.6 mm(2)) resolutions. Upon infusion of the bicuculline region-specific increases in CBV have been observed,suggesting CBV to reflect brain activity. During the first 2 min, the signal increases were predominant in the cortex, followed by increases in otherbrain areas, such as the caudate putamen, thalamus and cerebellum. Ten minutes after the start of infusion, a dominant response was observed in the thalamus, while in the caudate putamen a biphasic response pattern was seen. The magnitude of the signal responses in all brain regions was dependent on the dose of bicuculline and, in general, matched the known distribution of GABAA binding sites. This study suggests that pharmacological fMRI, displaying brain function at the highly specific level of drug-receptor interaction, should foster our understanding of normal and pathological brain function. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:17:36