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Titolo:
Simultaneous detection of changes in perfusion and BOLD contrast
Autore:
Schwarzbauer, C;
Indirizzi:
Max Planck Inst Cognit Neurosci, Leipzig, Germany Max Planck Inst Cognit Neurosci Leipzig Germany rosci, Leipzig, Germany
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 1, volume: 13, anno: 2000,
pagine: 37 -
SICI:
0952-3480(200001)13:1<37:SDOCIP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HUMAN-BRAIN; FUNCTIONAL MRI; INTRAVENOUS (H2O)-O-15; BLOOD OXYGENATION; FAIR TECHNIQUE; SPIN-ECHO; STIMULATION; ACTIVATION; GRADIENT;
Keywords:
cerebral blood flow; perfusion; BOLD contrast; quantification; fMRI; human brain mapping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzbauer, C Max Planck Inst Neuropsychol Forsch, Stephanstr 1A, D-04103 Leipzig, Germany Max Planck Inst Neuropsychol Forsch Stephanstr 1A Leipzig Germany D-04103
Citazione:
C. Schwarzbauer, "Simultaneous detection of changes in perfusion and BOLD contrast", NMR BIOMED, 13(1), 2000, pp. 37

Abstract

A new functional magnetic resonance imaging (fMRI) technique for simultaneous detection (SIDE) of changes in perfusion and blood oxygenation level dependent (BOLD) contrast is described. Perfusion contrast is generated by using magnetically labeled endogenous water proton spins as a freely diffusible tracer. A single slice-selective inversion pulse is combined with dual echo echo-planar imaging to generate a spin-echo (SE) image sensitive to changes in perfusion and a gradient-echo (GE) image sensitive to changes in both perfusion and BOLD contrast. The SIDE technique was applied to detect functional changes induced by a visual search task. A theoretical analysis isprovided to calculate quantitative maps of changes in cerebral blood flow (Delta CBF) and effective transverse relaxation time (Delta T-2*) from the corresponding signal changes in the SE and GE images. Since SE an GE imagesare generated from the same longitudinal magnetization, no errors due to spatial or temporal mismatch can arise in the quantification of Delta CBF and Delta T-2*. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:58:36