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Titolo:
P-31 MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake
Autore:
Larson-Meyer, DE; Newcomer, BR; Hunter, GR; Hetherington, HP; Weinsier, RL;
Indirizzi:
Univ Alabama, Dept Nutr Sci, Div Physiol & Metab, Birmingham, AL 35205 USAUniv Alabama Birmingham AL USA 35205 ol & Metab, Birmingham, AL 35205 USA Univ Alabama, Dept Crit & Diagnost Care, Birmingham, AL 35205 USA Univ Alabama Birmingham AL USA 35205 gnost Care, Birmingham, AL 35205 USA Univ Alabama, Dept Human Studies, Birmingham, AL 35205 USA Univ Alabama Birmingham AL USA 35205 an Studies, Birmingham, AL 35205 USA Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Lab, Dept Med, Upton, NY 11973 USA
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 1, volume: 13, anno: 2000,
pagine: 14 - 27
SICI:
0952-3480(200001)13:1<14:PMMOMF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; OXIDATIVE-METABOLISM; FIBER COMPOSITION; PRODUCTION-RATES; CREATINE-KINASE; ATP UTILIZATION; TIME COURSE; IN-VIVO; EXERCISE; RECOVERY;
Keywords:
muscle metabolism; oxidative capacity; reproducibility; validity; methodology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Larson-Meyer, DE Univ Alabama, Dept Nutr Sci, Div Physiol & Metab, 1675 Univ Blvd, Birmingham, AL 35205 USA Univ Alabama 1675 Univ Blvd Birmingham ALUSA 35205 5 USA
Citazione:
D.E. Larson-Meyer et al., "P-31 MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake", NMR BIOMED, 13(1), 2000, pp. 14-27

Abstract

The reliability, relation to whole-body maximal oxygen uptake (VO2max), and force-level sensitivity of P-31 MRS markers of mitochondrial function were studied in 39 normal-weight women. Following 90 s isometric plantar-flexion exercises at 45, 70 and 100% of maximum voluntary contraction, skeletal muscle mitochondrial function was determined from the phosphocreatine recovery time constant (TCPCr), the ADP recovery time constant (TCADP), and the rate of change in PCr during the first 14 s of recovery (OxPhos). VO2max was measured on a treadmill. Test-retest measurements were obtained in a subset of seven women. Overall, TCPCr, TCADP and OxPhos were reproducible for all exercises (coefficients of variation = 2.3-19.3%). With increasing force-level, TCPCr was prolonged (29.0 +/- 8.2, 31.9 +/- 9.0 and 35.4 +/- 9.5 s), OxPhos was increased (0.159 +/- 0.081, 0.247 +/- 0.090 and 0.310 +/- 0.114), and TCADP was Shortened (22.4 +/- 7.9, 21.3 +/- 6.2, and 19.5 +/- 6.7; p < 0.01). All MRS markers of mitochondrial function were correlated with VO2max (r=0.41-0.72; p<0.05). These results suggest that measurements of TCPCr, TCADP and OxPhos yield reproducible results that correlate with whole-body VO2max and that vary in force-level sensitivity. Copyright (C) 2000 John Wiley & Sons, Ltd.

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Documento generato il 11/07/20 alle ore 07:15:05