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Titolo:
Absence of the GluR2 receptor sensitizes mouse sympathetic neurons to nerve growth factor deprivation
Autore:
Lourenssen, S; Roder, JC; Blennerhassett, MG;
Indirizzi:
Queens Univ, Hotel Dieu Hosp, Gastrointestinal Dis Res Unit, Kingston, ON K7L 5G2, Canada Queens Univ Kingston ON Canada K7L 5G2 Unit, Kingston, ON K7L 5G2, Canada Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Fetal Hlth & Dev, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Dev, Toronto, ON M5G 1X5, Canada
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 281, anno: 2000,
pagine: 25 - 28
SICI:
0304-3940(20000303)281:1<25:AOTGRS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL; NEUROTOXICITY; HYPOTHESIS; EXPRESSION; DAMAGE; CELLS; LTP;
Keywords:
superior cervical ganglion; nerve growth factor; GluR2 subunit; (+/-)-alpha amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Blennerhassett, MG Queens Univ, Hotel Dieu Hosp, Gastrointestinal Dis Res Unit, 166 Brock St,Kingston, ON K7L 5G2, Canada Queens Univ 166 Brock St Kingston ON Canada K7L 5G2 ada
Citazione:
S. Lourenssen et al., "Absence of the GluR2 receptor sensitizes mouse sympathetic neurons to nerve growth factor deprivation", NEUROSCI L, 281(1), 2000, pp. 25-28

Abstract

Over-activation of glutamate receptors is implicated in neurodegeneration. Using mice with a deletion in the GluR2 gene, we studied the sensitivity of sympathetic neurons to reduced levels of nerve growth factor (NGF), whichcan cause neuronal cell death. Under standard culture conditions of 50 ng/ml NGF, neurons from the superior cervical ganglion survived and grew equally well compared with wild type controls. However, the subsequent reductionof NGF levels caused significantly poorer survival among mutant neurons by48 h, at 44 +/- 13% of control at 10 ng/ml NGF, and dropping further to 14+/- 6% at 0.05 ng/ml NGF. These results suggest that the absence of GluR2 impairs the ability of these NGF-sensitive neurons to survive under limiting amounts of this neurotrophic factor. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:05:36