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Titolo:
Increased vasomotor sympathetic nerve activity and decreased plasma nitricoxide release after head-down bed rest in humans: disappearance of correlation between vasoconstrictor and vasodilator
Autore:
Kamiya, A; Iwase, S; Michikami, D; Fu, Q; Mano, T; Kitaichi, K; Takagi, K;
Indirizzi:
Nagoya Univ, Environm Med Res Inst, Dept Auton Neurosci, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 a Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi 4618673, Japan Nagoya Univ Nagoya Aichi Japan 4618673 hnol, Nagoya, Aichi 4618673, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 281, anno: 2000,
pagine: 21 - 24
SICI:
0304-3940(20000303)281:1<21:IVSNAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC EXERCISE; DOGS;
Keywords:
bed rest; microneurography; muscle sympathetic nerve activity; vascular resistance; vasoconstrictor; vasodilator;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Mano, T Nagoya Univ, Environm Med Res Inst, Dept Auton Neurosci, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan Nagoya Univ Furo Cho Nagoya AichiJapan 4648601 chi 4648601, Japan
Citazione:
A. Kamiya et al., "Increased vasomotor sympathetic nerve activity and decreased plasma nitricoxide release after head-down bed rest in humans: disappearance of correlation between vasoconstrictor and vasodilator", NEUROSCI L, 281(1), 2000, pp. 21-24

Abstract

We hypothesized that the relationship between resting levels of sympathetic vasoconstrictor nerve traffic and dilator substance nitric oxide (NO) release is altered after exposure to microgravity, resulting in abnormal peripheral resistance. To examine the hypothesis, we assessed muscle sympatheticnerve activity (MSNA) (microneurography), an indicator of NO release (plasma nitrite/nitrate concentrations) a nd leg vascular resistance (venous occlusion plethysmography) in 20 healthy male volunteers before and after 14 days of 6 degrees head-down bed rest (HDBR), the ground-based analogue of microgravity. MSNA increased, while plasma nitrite/nitrate concentrations decreased after HDBR. A significant positive correlation observed between MSNAand plasma nitrite/nitrate concentrations before HDBR disappeared after HDBR. Leg vascular resistance increased after HDBR. In conclusion, an imbalance between sympathetic vasoconstrictor traffic and NO release might contribute to elevated peripheral vascular resistance following HDBR. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:49:03