Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Correlation between behavior and extracellular dopamine levels in rat striatum: comparison of microdialysis and fast-scan cyclic voltammetry
Autore:
Budygin, EA; Kilpatrick, MR; Gainetdinov, RR; Wightman, RM;
Indirizzi:
Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Chem, Chapel Hill, NC 27599 USA Duke Univ, Dept Cell Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Univ, Dept Cell Biol, Durham, NC 27710 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 281, anno: 2000,
pagine: 9 - 12
SICI:
0304-3940(20000303)281:1<9:CBBAED>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED STEREOTYPED BEHAVIOR; IN-VIVO; BRAIN MICRODIALYSIS; NUCLEUS ACCUMBENS; CORPUS STRIATUM; CAUDATE-NUCLEUS; IMPULSE FLOW; AMPHETAMINE; TRANSPORTER; INHIBITOR;
Keywords:
striatum; dopamine; fast-scan cyclic voltammetry; microdialysis; behavior; GBR 12909;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wightman, RM Univ N Carolina, Dept Chem, Venable Hall,CB 3290, Chapel Hill, NC 27599 USA Univ N Carolina Venable Hall,CB 3290 Chapel Hill NC USA 27599
Citazione:
E.A. Budygin et al., "Correlation between behavior and extracellular dopamine levels in rat striatum: comparison of microdialysis and fast-scan cyclic voltammetry", NEUROSCI L, 281(1), 2000, pp. 9-12

Abstract

Recently, fast-scan cyclic voltammetry (FSCV) has been adapted for real-time measurements of evoked dopamine (DA) release and uptake in freely movingrats. Using the advantages of this experimental design in combination withbehavioral measures, we examined the effect of GBR 12909 (20 mg/kg, i.p.),a selective DA uptake inhibitor, on striatal extracellular DA dynamics andcompared these data to that obtained by microdialysis. These studies established that both techniques report changes in DA that correlate with the kinetics of GBR 12909-induced behavioral effects. However, the time course ofchanges in evoked DA levels detected by FSCV was more closely linked with the changes in stereotypy than microdialysis measurements. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:27:13