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Titolo:
Preoperative FDG-PET temporal lobe hypometabolism and verbal memory after temporal lobectomy
Autore:
Griffith, HR; Perlman, SB; Woodard, AR; Rutecki, PA; Jones, JC; Ramirez, LF; DeLaPena, R; Seidenberg, M; Hermann, BP;
Indirizzi:
Univ Wisconsin, Dept Neurol, Madison, WI 53792 USA Univ Wisconsin MadisonWI USA 53792 n, Dept Neurol, Madison, WI 53792 USA Univ Wisconsin, Dept Radiol, Madison, WI 53792 USA Univ Wisconsin MadisonWI USA 53792 n, Dept Radiol, Madison, WI 53792 USA Univ Wisconsin, Dept Neurosurg, Madison, WI 53792 USA Univ Wisconsin Madison WI USA 53792 Dept Neurosurg, Madison, WI 53792 USA Chicago Med Sch, Dept Psychol, Chicago, IL USA Chicago Med Sch Chicago ILUSA go Med Sch, Dept Psychol, Chicago, IL USA William S Middleton Mem Vet Adm Hosp, Dept Neurol, Madison, WI USA WilliamS Middleton Mem Vet Adm Hosp Madison WI USA rol, Madison, WI USA William S Middleton Mem Vet Adm Hosp, Dept Neurosurg, Madison, WI USA William S Middleton Mem Vet Adm Hosp Madison WI USA urg, Madison, WI USA
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 54, anno: 2000,
pagine: 1161 - 1165
SICI:
0028-3878(20000314)54:5<1161:PFTLHA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERICTAL GLUCOSE HYPOMETABOLISM; POSITRON EMISSION TOMOGRAPHY; PARTIAL EPILEPSY; METABOLISM; PERFORMANCE; TOPOGRAPHY; SCALE;
Keywords:
PET; epilepsy surgery; neuropsychology; memory; anterior temporal lobectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hermann, BP Univ Wisconsin, Dept Neurol, 600 N Highland, Madison, WI 53792USA Univ Wisconsin 600 N Highland Madison WI USA 53792 I 53792 USA
Citazione:
H.R. Griffith et al., "Preoperative FDG-PET temporal lobe hypometabolism and verbal memory after temporal lobectomy", NEUROLOGY, 54(5), 2000, pp. 1161-1165

Abstract

Objective: To examine the relationship of preoperative fluorodeoxyglucose (FDG)-PET asymmetry in temporal lobe metabolism and memory outcome after anterior temporal lobectomy (ATL). Methods: In a university-based epilepsy surgery center, 60 ATL patients (27 left, 33 right) were divided into two groups: no/mild (n = 21) or moderate/ severe (n = 39) asymmetry in temporal lobe hypometabolism as determined by FDG-PET. All patients were nonretarded, at least 18 years of age, left-hemisphere speech dominant, without MRI abnormalities other than hippocampal atrophy, and with unilateral temporal lobeorigin of intractable complex partial seizures. Neuropsychological measures of intelligence and verbal and visual memory function were assessed preoperatively and 6 months postoperatively. Results: Left ATL patients with no/mild asymmetry in FDG-PET temporal lobe metabolism exhibited significantly greater verbal memory decline compared with left ATL patients with moderate/severe hypometabolism. There was no significant relationship between PET asymmetry and pre- to postsurgical IQ change. No significant relationship was observed between extent of PET hypometabolism and memory outcome for right ATL patients. Conclusions: FDG-PET asymmetry can be added to the preoperative clinical markers that appear useful in predicting verbal memory decline after left ATL.

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Documento generato il 04/04/20 alle ore 07:51:55