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Titolo:
Frequency and clinical determinants of dementia after ischemic stroke
Autore:
Desmond, DW; Moroney, JT; Paik, MC; Sano, M; Mohr, JP; Aboumatar, S; Tseng, CL; Chan, S; Williams, JBW; Remien, RH; Hauser, WA; Stern, Y;
Indirizzi:
SUNY Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA SUNY DownstateMed Ctr Brooklyn NY USA 11203 urol, Brooklyn, NY 11203 USA SUNY Downstate Med Ctr, Dept Pathol, Brooklyn, NY 11203 USA SUNY DownstateMed Ctr Brooklyn NY USA 11203 thol, Brooklyn, NY 11203 USA Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Biostat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 54, anno: 2000,
pagine: 1124 - 1131
SICI:
0028-3878(20000314)54:5<1124:FACDOD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASE-LINE FREQUENCY; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; DIAGNOSTIC-CRITERIA; BRAIN INFARCTION; MEMORY; CONFIRMATION; PREVALENCE; POPULATION; EDUCATION;
Keywords:
stroke; cerebrovascular disease; dementia; vascular dementia; AD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Desmond, DW SUNY Downstate Med Ctr, Dept Neurol, 450 Clarkson Ave,Box 25, Brooklyn, NY11203 USA SUNY Downstate Med Ctr 450 Clarkson Ave,Box 25 Brooklyn NY USA 11203
Citazione:
D.W. Desmond et al., "Frequency and clinical determinants of dementia after ischemic stroke", NEUROLOGY, 54(5), 2000, pp. 1124-1131

Abstract

Objective: To investigate the frequency and clinical determinants of dementia after ischemic stroke. Methods: The authors administered neurologic, neuropsychological, and functional assessments to 453 patients (age 72.0 +/- 8.3 years) 3 months after ischemic stroke. They diagnosed dementia using modified Diagnostic and Statistical Manual of Mental Disorders, 3rd ed., revised criteria requiring deficits in memory and two or more additional cognitive domains as well as functional impairment. Results: The authors diagnosed dementia in 119 of the 453 patients (26.3%). Regarding dementia subtypes,68 of the 119 patients (57.1%) were diagnosed with vascular dementia, 46 patients (38.7%) were diagnosed with AD with concomitant stroke, and 5 patients (4.2%) had dementia for other reasons. Logistic regression suggested that dementia was associated with a major hemispheral stroke syndrome (OR 3.0), left hemisphere (OR 2.1) and right hemisphere (OR 1.8) infarct locationsversus brainstem/cerebellar locations, infarcts in the pooled anterior andposterior cerebral artery territories versus infarcts in other vascular territories (OR 1.7), diabetes mellitus (OR 1.8), prior stroke (OR 1.7), age 80 years or older (OR 12.1) and 70 to 79 years (OR 3.9) versus 60 to 69 years, 8 or fewer years of education (OR 4.1) and: 9 to 12 years of education (OR 3.0) versus 13 or more years of education, black race (OR 2.6) and Hispanic ethnicity (OR 3.1) versus white race, and northern Manhattan residence(OR 1.6). Conclusions: Dementia is frequent after ischemic stroke, occurring in one-fourth of the elderly patients in the authors' cohort. The clinical determinants of dementia include the location and severity of the presenting stroke, vascular risk factors such as diabetes mellitus and prior stroke, and host characteristics such as older age, fewer years of education, and nonwhite race/ethnicity. The results also suggest that concomitant AD plays an etiologic role in approximately one-third of cases of dementia afterstroke.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:12:26