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Titolo:
Structural genomics and its importance for gene function analysis
Autore:
Skolnick, J; Fetrow, JS; Kolinski, A;
Indirizzi:
Danforth Plant Sci Ctr, Lab Computat Genom, St Louis, MO 63141 USA Danforth Plant Sci Ctr St Louis MO USA 63141 enom, St Louis, MO 63141 USA Geneformat Inc, San Diego, CA 92121 USA Geneformat Inc San Diego CA USA 92121 format Inc, San Diego, CA 92121 USA Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland Univ Warsaw Warsaw Poland PL-02093 w, Dept Chem, PL-02093 Warsaw, Poland
Titolo Testata:
NATURE BIOTECHNOLOGY
fascicolo: 3, volume: 18, anno: 2000,
pagine: 283 - 287
SICI:
1087-0156(200003)18:3<283:SGAIIF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TO-FUNCTION PARADIGM; PROTEIN FOLDS; DATABASE; SEQUENCE; CLASSIFICATION; IDENTIFICATION; PREDICTION; PATTERNS; REVEALS; BETA;
Keywords:
protein folding; threading; protein function prediction; structural genomics; functional motifs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Skolnick, J Danforth Plant Sci Ctr, Lab Computat Genom, 893 N,Warson Rd, St Louis, MO 63141 USA Danforth Plant Sci Ctr 893 N,Warson Rd St Louis MO USA 63141 A
Citazione:
J. Skolnick et al., "Structural genomics and its importance for gene function analysis", NAT BIOTECH, 18(3), 2000, pp. 283-287

Abstract

Structural genomics projects aim to solve the experimental structures of all possible protein folds. Such projects entail a conceptual shift from traditional structural biology in which structural information is obtained on known proteins to one in which the structure of a protein is determined first and the function assigned only later. Whereas the goal of converting protein structure into function can be accomplished by traditional sequence motif-based approaches, recent studies have shown that assignment of a protein's biochemical function can also be achieved by scanning its structure fora match to the geometry and chemical identity of a known active site. Importantly, this approach can use tow-resolution structures provided by contemporary structure prediction methods. When applied to genomes, structural information (either experimental or predicted) is likely to play an importantrole in high-throughput function assignment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:26:44