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Titolo:
Growth patterns in the developing brain detected by using continuum mechanical tensor maps
Autore:
Thompson, PM; Gledd, JN; Woods, RP; MacDonald, D; Evans, AC; Toga, AW;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Div Brain Mapping, Dept Neurol,Lab Neuroimaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA NIMH, Child Psychiat Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MDUSA 20892 d Psychiat Branch, NIH, Bethesda, MD 20892 USA McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
NATURE
fascicolo: 6774, volume: 404, anno: 2000,
pagine: 190 - 193
SICI:
0028-0836(20000309)404:6774<190:GPITDB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; IMAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, PM Univ Calif Los Angeles, Sch Med, Div Brain Mapping, Dept Neurol,Lab Neuroimaging, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
P.M. Thompson et al., "Growth patterns in the developing brain detected by using continuum mechanical tensor maps", NATURE, 404(6774), 2000, pp. 190-193

Abstract

The dynamic nature of growth and degenerative disease processes requires the design of sensitive strategies to detect, track and quantify structural change in the brain in its full spatial and temporal complexity(1). Although volumes of brain substructures are known to change during development(2),detailed maps of these dynamic growth processes have been unavailable. Here we report the creation of spatially complex, four-dimensional quantitative maps of growth patterns in the developing human brain, detected using a tensor mapping strategy with greater spatial detail and sensitivity than previously obtainable. By repeatedly scanning children (aged 3-15 years) across time spans of up to four years, a rostro-caudal wave of growth was detected at the corpus callosum, a fibre system that relays information between brain hemispheres. Peak growth rates, in fibres innervating association and language cortices, were attenuated after puberty, and contrasted sharply with a severe, spatially localized loss of subcortical grey matter. Conversely, at ages 3-6 years, the fastest growth rates occurred in frontal networksthat regulate the planning of new actions. Local rates, profiles, and principal directions of growth were visualized in each individual child.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:27:21