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Titolo:
Cortical deficits in multiple sclerosis on the basis of subcortical lesions
Autore:
Jeffery, DR; Absher, J; Pfeiffer, FE; Jackson, H;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Neurol, Sticht Ctr, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
MULTIPLE SCLEROSIS
fascicolo: 1, volume: 6, anno: 2000,
pagine: 50 - 55
SICI:
1352-4585(200002)6:1<50:CDIMSO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEST-PERFORMANCE; BRAIN-LESIONS; APHASIA; MRI; NEUROPSYCHOLOGY; PATTERNS;
Keywords:
multiple sclerosis; positron emission tomography; cognitive function; cortical hypometabolism; immunotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Jeffery, DR Wake Forest Univ, Sch Med, Dept Neurol, Sticht Ctr, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake Forest Univ Med Ctr Blvd Winston SalemNC USA 27157 7 USA
Citazione:
D.R. Jeffery et al., "Cortical deficits in multiple sclerosis on the basis of subcortical lesions", MULT SCLER, 6(1), 2000, pp. 50-55

Abstract

Patients suffering fron multiple sclerosis have a high frequency of cognitive deficits usually attributable to demyelination and axonal loss in the subcortical white matter. Neurologic abnormalities referable to cortical function ore uncommon but have been described. The present study describes three patients with clinically definite MS with deficits in cognitive functionreferable to cortical location. Two of the patients underwent positron emission tomography and showed profound cortical hypometabolism adjacent to subcortical white matter lesions seen on MRI. This paper points out that neurologic deficits referable to cortical sites may be caused by subcortical white matter lesions and that cognitive dysfunction in patients with MS may progress rapidly in the absence of motoria deficits or other evidence of clinical deterioration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:03:47