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Titolo:
Impact of insulin resistance on lipoprotein subpopulation distribution in lean and morbidly obese nondiabetic women
Autore:
MacLean, PS; Vadlamudi, S; MacDonald, KG; Pories, WJ; Houmard, JA; Barakat, HA;
Indirizzi:
E Carolina Univ, Sch Med, Dept Biochem, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Biochem, Greenville, NC 27858 USA E Carolina Univ, Sch Med, Dept Surg, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 pt Surg, Greenville, NC 27858 USA E Carolina Univ, Human Performance Lab, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 nce Lab, Greenville, NC 27858 USA
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 3, volume: 49, anno: 2000,
pagine: 285 - 292
SICI:
0026-0495(200003)49:3<285:IOIROL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY DISEASE; DEPENDENT DIABETES-MELLITUS; IMPAIRED GLUCOSE-TOLERANCE; TRIGLYCERIDE-METABOLISM; PARTICLE-SIZE; HEART-DISEASE; LDL SIZE; MYOCARDIAL-INFARCTION; APOLIPOPROTEIN-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Barakat, HA E Carolina Univ, Sch Med, Dept Biochem, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 enville, NC 27858 USA
Citazione:
P.S. MacLean et al., "Impact of insulin resistance on lipoprotein subpopulation distribution in lean and morbidly obese nondiabetic women", METABOLISM, 49(3), 2000, pp. 285-292

Abstract

The purpose of this study was to examine the effects of insulin resistanceon the lipoprotein subpopulation distribution of very-low-density, low-density, and high-density lipoproteins (VLDL, LDL, and HDL) in lean and morbidly obese nondiabetic women. Lean women (body mass index [BMI], 20 to 27 kg/m(2)) stratified by BMI were divided into insulin-sensitive (SL, n = 12) and insulin-resistant (RL, n = 8) groups according to Bergman's minimal model, SI. A group of obese women (BMI, 30 to 53 kg/m(2)), also stratified by BMI, were divided into insulin-sensitive (SO, n = 10) and insulin-resistant (RO, n = 11) groups in a similar fashion, Resistant groups were similar to sensitive groups (SL v RL and SO v RO) in age, weight, percent body fat, andwaist circumference, ie, total and regional adiposity. VLDL, LDL, and HDL subpopulation distributions were determined in fasting plasma samples by nuclear magnetic resonance (NMR) spectroscopy. The average particle sizes of all 3 classes of lipoproteins were similar for the SL and RL groups. In contrast, RO subjects had larger VLDL, smaller LDL, and smaller HDL, than SO subjects (P < .05), Lower concentrations of large LDL and large HDL were found in RO compared with SO subjects (P < .05), In obese women, but not in lean women, VLDL size was associated with plasma insulin (r = .60, P < .005),while LDL size and HDL size were negatively correlated with plasma insulin(r = -.39, P < .05 and r = -.38, P < .05) and positively correlated with SI (r = .54, P < .01 and r = .42, P < .05). These results suggest that in obese women, insulin resistance may be involved in the formation of lipoprotein subpopulation distributions that are associated with vascular disease. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:37:27