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Titolo:
The role of parenteral antischistosomal therapy in the spread of hepatitisC virus in Egypt
Autore:
Frank, C; Mohamed, MK; Strickland, GT; Lavanchy, D; Arthur, RR; Magder, LS; El Khoby, T; Abdel-Wahab, Y; Ohn, EA; Anwar, W; Sallam, I;
Indirizzi:
Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Prevent Med, Baltimore, MD 21201 USA Ain Shams Univ, Fac Med, Dept Community Environm & Occupat Med, Cairo, Egypt Ain Shams Univ Cairo Egypt mmunity Environm & Occupat Med, Cairo, Egypt WHO, Div Communicable Dis Surveillance & Response, CH-1211 Geneva, Switzerland WHO Geneva Switzerland CH-1211 e & Response, CH-1211 Geneva, Switzerland Egyptian Minist Hlth & Populat, Cairo, Egypt Egyptian Minist Hlth & Populat Cairo Egypt Hlth & Populat, Cairo, Egypt
Titolo Testata:
LANCET
fascicolo: 9207, volume: 355, anno: 2000,
pagine: 887 - 891
SICI:
0140-6736(20000311)355:9207<887:TROPAT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH SEROPREVALENCE; BLOOD-DONORS; B INFECTION; SCHISTOSOMIASIS; PREVALENCE; GENOTYPES; REGIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Strickland, GT Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 ltimore, MD 21201 USA
Citazione:
C. Frank et al., "The role of parenteral antischistosomal therapy in the spread of hepatitisC virus in Egypt", LANCET, 355(9207), 2000, pp. 887-891

Abstract

Background The population of Egypt has a heavy burden of liver disease, mostly due to chronic infection with hepatitis C virus (HCV). Overall prevalence of antibody to HCV in the general population is around 15-20%. The riskfactor for HCV transmission that specifically sets Egypt apart from other countries is a personal history of parenteral antischistosomal therapy (PAT). A review of the Egyptian PAT mass-treatment campaigns, discontinued onlyin the 1980s, show a very high potential for transmission of blood-borne pathogens. We examine the relative importance of PAT in the spread of HCV inEgypt. Methods The degree of exposure to PAT by cohort was estimated from 1961-86Ministry of Health data. A cohort-specific exposure index for PAT was calculated and compared with cohort-specific HCV prevalence rates in four regions. Findings HCV prevalence was calculated for 8499 Egyptians aged 10-50 years. A significant association between seroprevalence of antibodies to HCV andthe exposure index (1.31 [95% CI 1.08-1.59]; p=0.007) was identified across four different regions. In all regions cohort-specific HCV prevalence waslowest in children and young adults than in older cohorts. These lower prevalence rates coincided with the gradual and final replacement of PAT with oral antischistosomal drugs at different points in time in the four regions. Interpretation The data suggest that PAT had a major role in the spread ofHCV throughout Egypt. This intensive transmission established a large reservoir of chronic HCV infection, responsible for the high prevalence of HCV infection and current high rates of transmission. Egypt's mass campaigns ofPAT may represent the world's largest iatrogenic transmission of blood-borne pathogens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:24:01