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Titolo:
The effect of oral and intravenous methylprednisolone treatment on subsequent relapse rate in multiple sclerosis
Autore:
Sharrack, B; Hughes, RAC; Morris, RW; Soudain, S; Wade-Jones, O; Barnes, D; Brown, P; Britton, T; Francis, DA; Perkin, GD; Rudge, P; Swash, M; Katifi, HA; Farmer, S; Frankel, JP;
Indirizzi:
Guys Kings & St Thomas Sch Med, London, England Guys Kings & St Thomas SchMed London England Sch Med, London, England Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England Royal Hallamshire Hosp Sheffield S Yorkshire England S10 2JF ire, England Royal Free & Univ Coll Med Sch, London, England Royal Free & Univ Coll MedSch London England Med Sch, London, England Atkinson Morleys Hosp, London, England Atkinson Morleys Hosp London England nson Morleys Hosp, London, England Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England Queen Elizabeth Hosp, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Hosp Birmingham W Midlands England B15 2TH lands, England Charing Cross Hosp, London, England Charing Cross Hosp London EnglandCharing Cross Hosp, London, England Royal London Hosp, London E1 1BB, England Royal London Hosp London England E1 1BB don Hosp, London E1 1BB, England Wessex Neurol Ctr, Southampton, Hants, England Wessex Neurol Ctr Southampton Hants England Southampton, Hants, England
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 173, anno: 2000,
pagine: 73 - 77
SICI:
0022-510X(20000201)173:1<73:TEOOAI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPTIC NEURITIS; CONTROLLED TRIAL; FOLLOW-UP; THERAPY; CORTICOSTEROIDS; DISABILITY; PLACEBO; DISEASE;
Keywords:
multiple sclerosis; steroids; methylprednisolone; relapse rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Hughes, RAC Guys Kings & St Thomas Sch Med, London, England Guys Kings & St Thomas Sch Med London England ndon, England
Citazione:
B. Sharrack et al., "The effect of oral and intravenous methylprednisolone treatment on subsequent relapse rate in multiple sclerosis", J NEUR SCI, 173(1), 2000, pp. 73-77

Abstract

We investigated the effect of oral and intravenous methylprednisolone treatment on subsequent relapse rate in patients with multiple sclerosis. Following a double blind trial designed to compare the effect of oral and intravenous methylprednisolone treatment on promoting recovery from acute relapses of multiple sclerosis, 80 patients were followed for two years with six-monthly assessments during which all subsequent relapses were recorded. The annual relapse rate was slightly higher in the oral compared with the intravenous methylprednisolone-treated patients (1.06 vs. 0.78), but the adjusted difference between the two groups was not statistically significant (0.18; 95% CI -0.19 to 0.55, P=0.3). The time to onset and the severity of the first relapse after treatment, the number of relapse free patients at the end of the follow-up period, and the severity of the relapses during the follow-up period were similar in the two groups. This trial did not show a statistically significant difference in relapse rate during the first two yearsfollowing oral compared with intravenous methylprednisolone treatment. (C)2000 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:26:10