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Titolo:
Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica
Autore:
Herrero, R; Hildesheim, A; Bratti, C; Sherman, ME; Hutchinson, M; Morales, J; Balmaceda, I; Greenberg, MD; Alfaro, M; Burk, RD; Wacholder, S; Plummer, M; Schiffman, M;
Indirizzi:
Minist Hlth, San Jose, Costa Rica Minist Hlth San Jose Costa RicaMinist Hlth, San Jose, Costa Rica Int Agcy Res Canc, F-69372 Lyon, France Int Agcy Res Canc Lyon France F-69372 gcy Res Canc, F-69372 Lyon, France NCI, Epidemiol & Biostat Program, Div Canc Epidemiol & Genet, Bethesda, MD20892 USA NCI Bethesda MD USA 20892 v Canc Epidemiol & Genet, Bethesda, MD20892 USA Caja Costarricense Seguro Social, San Jose, Costa Rica Caja Costarricense Seguro Social San Jose Costa Rica n Jose, Costa Rica Johns Hopkins Med Inst, Dept Pathol & Gynecol & Obstet, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 et, Baltimore, MD 21205 USA Brown Univ, Women & Infants Hosp, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 Infants Hosp, Providence, RI 02912 USA Omnia Corp, Philadelphia, PA USA Omnia Corp Philadelphia PA USAOmnia Corp, Philadelphia, PA USA Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA Albert EinsteinColl Med Bronx NY USA 10467 t Pediat, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Immunol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10467 USAAlbert Einstein Coll Med Bronx NY USA 10467 cial Med, Bronx, NY 10467 USA
Titolo Testata:
JOURNAL OF THE NATIONAL CANCER INSTITUTE
fascicolo: 6, volume: 92, anno: 2000,
pagine: 464 - 474
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK-FACTORS; INTRAEPITHELIAL NEOPLASIA; HPV DNA; CANCER; WOMEN; PREVALENCE; ASSOCIATION; COLOMBIA; TYPE-52; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Herrero, R Proyecto Epidemiol Guanacaste, POB 301-6151, San Jose, Costa Rica Proyecto Epidemiol Guanacaste POB 301-6151 San Jose Costa Rica
Citazione:
R. Herrero et al., "Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica", J NAT CANC, 92(6), 2000, pp. 464-474

Abstract

Background: Human papillomavirus (HPV) is the main cause of cervical neoplasia, Because few population-based studies have investigated the prevalenceof type-specific infection in relation to cervical disease, we studied a high-risk population, estimating the prevalence of HPV infection and the risk associated with various HPV types. Methods: We screened 9175 women in Guanacaste, Costa Rica, to obtain a referent standard final diagnosis, and tested 3024 women for more than 40 types of HPV with a polymerase chain reaction-based system. Results: Among women with normal cytology, HPV infections peaked first in women younger than 25 gears, and they peaked again at age 55 years or older with predominantly non-cancer-associated types of HPV and uncharacterized HPV types. Low-grade squamous intraepithelial lesions (LSILs) (n = 189) decreased consistently with age. The prevalence of high-grade squamous intraepithelial lesions (HSILs) (n = 128) peaked first around age 30 years and again at age 65 years or older. Seventy-three percent of LSILswere HPV positive, with HPV16 being the predominant type (16% of positive subjects). HPV was found in 89% of HSILs and 88% of cancers, with HPV16 being strongly predominant (51% and 53% of positive subjects). Virtually all HSILs and cancers had cancer-associated HPV types, with high odds ratios (ORs) and attributable fractions around 80%, Risk for HPV16 was particularly high (OR for HSILs = 320, 95% confidence interval [CI] = 97-1000; OR for cancer = 710, 95% CI = 110-4500), Conclusions: We confirm the early decline ofHPV infection with age but note increased prevalence after menopause, which could be related to a second peak of HSILs, an observation that warrants further investigation, At least 80% of HPVs involved in cervical carcinogenesis in this population have been characterized. Polyvalent vaccines including the main cancer-associated HPV types may be able to prevent most cases of cervical disease in this region.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:49:43