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Titolo:
Measurement of dopamine release with continuous infusion of [C-11]raclopride: Optimization and signal-to-noise considerations
Autore:
Watabe, H; Endres, CJ; Breier, A; Schmall, B; Eckelman, WC; Carson, RE;
Indirizzi:
NIMH, PET Dept, Ctr Clin, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 ET Dept, Ctr Clin, NIH, Bethesda, MD 20892 USA NIMH, Expt Therapeut Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MDUSA 20892 Therapeut Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 41, anno: 2000,
pagine: 522 - 530
SICI:
0161-5505(200003)41:3<522:MODRWC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE BINDING; NONHUMAN-PRIMATES; PET; MICRODIALYSIS; SCHIZOPHRENIA; INVIVO; BOLUS;
Keywords:
[C-11]raclopride; bolus/infusion; amphetamine; noise; optimization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Carson, RE NIMH, PET Dept, Ctr Clin, NIH, Bldg 10,Rm 1C-401,10 Ctr Dr,MSC 1180, Bethesda, MD 20892 USA NIMH Bldg 10,Rm 1C-401,10 Ctr Dr,MSC 1180 Bethesda MD USA 20892
Citazione:
H. Watabe et al., "Measurement of dopamine release with continuous infusion of [C-11]raclopride: Optimization and signal-to-noise considerations", J NUCL MED, 41(3), 2000, pp. 522-530

Abstract

PET studies with [C-11]raclopride provide an indirect measure of changes in synaptic dopamine. Previously, we used the bolus-plus-infusion (B/I) method to assess dopamine response from the percentage change in binding potential (Delta BP) before and after administration of amphetamine. The goal of this work is to optimize the measurement of changes in neurotransmitter with the B/I method by choosing the optimal timing for pre- and poststimulus scanning. Methods: Two sources of variability in Delta BP were considered: within-subject and between-subject noise. A noise model based on a phantom study and human data was used to evaluate the within-subject noise. For between-subject noise, simulated time-activity curves were generated from measured [C-11]raclopride input functions. Optimal timing to measure bBP was determined and applied to human data. Results: According to the simulation study, the optimal scan times for pre- and poststimulus scans were 39-50 and 58-100 min, respectively. The optimal timing resulted in a 28% noise reduction compared with the original timing. By applying the optimal timing to human studies, the statistical significance of the difference in Delta BP between patients with schizophrenia and healthy volunteers increased from P = 0.038 to 0.012. Conclusion: careful assessment of the sources of noise in receptor imaging studies can increase the sensitivity of the B/I method for the detection of biologic signals.

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Documento generato il 03/06/20 alle ore 00:01:55