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Titolo:
Receiver operating characteristic evaluation of iterative reconstruction with attenuation correction in Tc-99m-sestamibi myocardial SPECT images
Autore:
LaCroix, KJ; Tsui, BMW; Frey, EC; Jaszczak, RJ;
Indirizzi:
Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Engn, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 adiol, Chapel Hill, NC 27599 USA Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ, Dept Biomed Engn, Durham, NC 27710 USA Duke Univ Durham NC USA27710 niv, Dept Biomed Engn, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 41, anno: 2000,
pagine: 502 - 513
SICI:
0161-5505(200003)41:3<502:ROCEOI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; SCATTER RESPONSE FUNCTION; CORONARY-ARTERY DISEASE; NONUNIFORM ATTENUATION; PERFUSION TOMOGRAPHY; DIAGNOSTIC-ACCURACY; TL-201; COMPENSATION; ROC; ANGIOGRAPHY;
Keywords:
cardiac SPECT; attenuation correction; Tc-99m-sestamibi radionuclide; ROC study; phantom study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: LaCroix, KJ Univ N Carolina, Dept Biomed Engn, CB 7575,152 MacNider, Chapel Hill, NC 27599 USA Univ N Carolina CB 7575,152 MacNider Chapel Hill NC USA 27599
Citazione:
K.J. LaCroix et al., "Receiver operating characteristic evaluation of iterative reconstruction with attenuation correction in Tc-99m-sestamibi myocardial SPECT images", J NUCL MED, 41(3), 2000, pp. 502-513

Abstract

The purpose of this study was to evaluate differences in myocardial defectdetection between Tc-99m-sestamibi myocardial SPECT images reconstructed using conventional filtered backprojection (FBP) without attenuation correction (AC) and those reconstructed using maximum-likelihood expectation maximization with nonuniform attenuation correction (MLAC). Methods: An observerstudy and receiver operating characteristic (ROC) curve analysis were performed using simulated Tc-99m-sestamibi SPECT data from a population of 24 mathematic anthropomorphic torso phantoms, which realistically modeled a wide range of anatomic variations. The phantoms modeled male patients with a flat diaphragm, male patients with a diaphragm raised to the level of the heart, and female patients with large breasts, Transmural, cold defects with a contrast of 0.25 were simulated in the left ventricular wall for 6 locations. Noisy projection data were generated from the phantoms and included the effects of nonuniform attenuation, collimator-detector response, and scatter. The data were then reconstructed using FBP and MLAC. Images were displayed in the short- and long-axis formats, as in clinical practice. Eight observers viewed blocks of FBP and MLAC images and, for each image, indicatedon a continuous rating scale the probability that a defect was present. From the rating data, FBP and MLAC ROC curves were generated, and their areas(A,) were estimated and compared. Results: In general, the FBP and MLAC ROC curves did not cross and the MLAC curve showed a higher A, than did the corresponding FBP curve. For male phantoms with a flat diaphragm, the average difference in A,was 0.04 and was not statistically significant (at the P = 0.05 level) for 6 of 8 observers. For male phantoms with a raised diaphragm, the average difference in 8, was 0.22 and was statistically significantfor 6 of 8 observers. For female phantoms with large breasts, the average difference in A, was 0.19 and was statistically significant for all 8 observers. Conclusion: This study showed an improvement in defect detection in myocardial SPECT images using MLAC in comparison with images using FBP without AC, particularly for patients with large breasts or with a diaphragm raised to the level of the heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:30:24