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Titolo:
Theoretical study on mutation-induced activation of the luteinizing hormone receptor
Autore:
Fanelli, F;
Indirizzi:
Univ Modena & Reggio Emilia, Dipartimento Chim, I-41100 Modena, Italy UnivModena & Reggio Emilia Modena Italy I-41100 , I-41100 Modena, Italy
Titolo Testata:
JOURNAL OF MOLECULAR BIOLOGY
fascicolo: 5, volume: 296, anno: 2000,
pagine: 1333 - 1351
SICI:
0022-2836(20000310)296:5<1333:TSOMAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; LIMITED PRECOCIOUS PUBERTY; MEMBRANE-SPANNING SEGMENT; BINDING-SITE CREVICE; DOPAMINE D2 RECEPTOR; 3RD INTRACELLULAR LOOP; LUTROPIN-CHORIOGONADOTROPIN RECEPTOR; HUMAN CHORIONIC-GONADOTROPIN; M5 MUSCARINIC RECEPTOR; LEYDIG-CELL HYPOPLASIA;
Keywords:
luteinizing hormone receptor; G proteins; receptor activation; molecular dynamics; constitutive activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Fanelli, F Univ Modena & Reggio Emilia, Dipartimento Chim, Via Campi 183, I-41100 Modena, Italy Univ Modena & Reggio Emilia Via Campi 183 Modena Italy I-41100
Citazione:
F. Fanelli, "Theoretical study on mutation-induced activation of the luteinizing hormone receptor", J MOL BIOL, 296(5), 2000, pp. 1333-1351

Abstract

Here, three-dimensional model building and molecular dynamics simulations of the luteinizing hormone receptor have been employed to generate hypotheses about the molecular mechanisms underlying the activation of the receptorinduced by naturally occurring activating mutations. The comparative analysis of the wild-type receptor and of 16 constitutively active or inactive mutants has been instrumental in inferring the structural/dynamic features which could characterize the inactive and the active forms of the receptor. These features have been also employed for predicting the functional behavior of new receptor mutants. The results of this study might provide a structural framework to interpret the pathological effects induced by mutations of the luteinizing hormone receptor. In addition, the proposed theoretical model could be useful for engineering new mutations or ligands able to modulate receptor function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:19:38