Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response
Autore:
Born, TL; Morrison, LA; Esteban, DJ; VandenBos, T; Thebeau, LG; Chen, NH; Spriggs, MK; Sims, JE; Buller, RML;
Indirizzi:
St Louis Univ, Dept Mol Microbiol & Immunol, St Louis, MO 63104 USA St Louis Univ St Louis MO USA 63104 iol & Immunol, St Louis, MO 63104 USA Immunex Corp, Seattle, WA 98101 USA Immunex Corp Seattle WA USA 98101Immunex Corp, Seattle, WA 98101 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 164, anno: 2000,
pagine: 3246 - 3254
SICI:
0022-1767(20000315)164:6<3246:APPTBT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-INDUCING FACTOR; NF-KAPPA-B; IFN-GAMMA; INTERFERON-GAMMA; T-CELLS; VACCINIA VIRUS; NATURAL-KILLER; MYXOMA VIRUS; CHEMOKINE ACTIVITY; ECTROMELIA VIRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Sims, JE St Louis Univ, Dept Mol Microbiol & Immunol, 1402 S Grand Blvd, St Louis, MO 63104 USA St Louis Univ 1402 S Grand Blvd St Louis MO USA 63104O 63104 USA
Citazione:
T.L. Born et al., "A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response", J IMMUNOL, 164(6), 2000, pp. 3246-3254

Abstract

IL-18 induces IFN-gamma and NK cell cytotoxicity, making it a logical target for viral antagonism of host defense. We demonstrate that the ectromeliapoxvirus p13 protein, bearing homology to the mammalian IL-18 binding protein, binds IL-18, and inhibits its activity in vitro. Binding of IL-18 to the viral p13 protein was compared with binding to the cellular IL-18R, The dissociation constant of p13 For murine IL-18 is 5 nM, compared with 0.2 nMfor the cellular receptor heterodimer. Mice infected with a p13 deletion mutant of ectromelia virus had elevated cytotoxicity for YAC-1 tumor cell targets compared with control animals. Additionally, the p13 deletion mutant virus exhibited decreased levels of infectivity. Our data suggest that inactivation of IL-18, and subsequent impairment of NK cell cytotoxicity, may be one mechanism by which ectrometia evades the host immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:14:51