Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LST1: A gene with extensive alternative splicing and immunomodulatory function
Autore:
Rollinger-Holzinger, I; Eibl, B; Pauly, M; Griesser, U; Hentges, F; Auer, B; Pall, G; Schratzberger, P; Niederwieser, D; Weiss, EH; Zwierzina, H;
Indirizzi:
Lab Rech Canc & Malad Sang, L-1511 Luxembourg, Luxembourg Lab Rech Canc & Malad Sang Luxembourg Luxembourg L-1511 ourg, Luxembourg Univ Innsbruck Hosp, Dept Internal Med, Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria Internal Med, Innsbruck, Austria Ctr Hosp, Dept Immunol & Allergol, Luxembourg, Luxembourg Ctr Hosp Luxembourg Luxembourg munol & Allergol, Luxembourg, Luxembourg Innsbruck Univ, Inst Biochem, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 ochem, A-6020 Innsbruck, Austria Univ Leipzig, Dept Hematol Oncol, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 matol Oncol, D-7010 Leipzig, Germany Inst Anthropol & Human Genet, Munich, Germany Inst Anthropol & Human Genet Munich Germany uman Genet, Munich, Germany
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 164, anno: 2000,
pagine: 3169 - 3176
SICI:
0022-1767(20000315)164:6<3169:LAGWEA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; MONONUCLEAR-CELLS; DENDRITIC CELLS; LYMPHOCYTES-B; HUMAN BLOOD; TNF REGION; POLYMORPHISM; EXPRESSION; LOCUS; BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Rollinger-Holzinger, I Ctr Univ, Ave Faiencerie 162A, L-1511 Luxembourg, Luxembourg Ctr Univ Ave Faiencerie 162A Luxembourg Luxembourg L-1511
Citazione:
I. Rollinger-Holzinger et al., "LST1: A gene with extensive alternative splicing and immunomodulatory function", J IMMUNOL, 164(6), 2000, pp. 3169-3176

Abstract

The gene of the leukocyte-specific transcript (LST1) is encoded within theTNF region of the human MHC. The LST1 gene is constitutively expressed in leukocytes and dendritic cells, and it is characterized by extensive alternative splicing. We identified 7 different LST1 splice variants in PBMC; thus, 14 LST1 splice variants (LST1/A-LST1/N) have been detected in various cell types. These isoforms code for transmembrane as well as soluble LST1 proteins characterized by two alternative open reading frames at their 3' end. We demonstrate the presence of the transmembrane variant LST1/C on the cell surface of the monocytic cell lines U937 and THP1. Recombinant expressionof LST1/C permitted its profound inhibitory effect on lymphocyte proliferation to be observed. In contrast, the alternative transmembrane variant LST1/A, the extracellular domain of which shows no amino acid sequence homology to LST1/C exerted a weaker but similar inhibitory effect on PBMC. These data demonstrate the protein expression of LST1 on the cell surface of mononuclear cells, and they show an inhibitory effect on lymphocyte proliferation of two LST1 proteins although they have only a very short amino acid homology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 02:16:43