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Titolo:
Alveolar environment influences the metabolic and biophysical properties of exogenous surfactants
Autore:
Puligandla, PS; Gill, T; McCaig, LA; Yao, LJ; Veldhuizen, RAW; Possmayer, F; Lewis, JF;
Indirizzi:
Univ Western Ontario, Lawson Res Inst, Dept Med, St Josephs Hlth Ctr, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, Dept Physiol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, London Hlth Sci Ctr, MRC Grp Fetal & Neonatal Hlth &Dev, Dept Obstet & Gynecol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 88, anno: 2000,
pagine: 1061 - 1071
SICI:
8750-7587(200003)88:3<1061:AEITMA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; ACUTE LUNG INJURY; PULMONARY SURFACTANT; PRETERM LAMBS; PROTEIN-A; SP-C; RABBITS; INVITRO; CONVERSION; ASPIRATION;
Keywords:
acute respiratory distress syndrome; surfactant metabolism; biophysical properties; surface area cycling; bovine lipid extract surfactant; recombinant surfactant-associated protein C drug product; surfactant aggregates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, JF Univ Western Ontario, Lawson Res Inst, Dept Med, St Josephs HlthCtr, Rm H417,268 Grosvenor St, London, ON N6A 4V2, Canada Univ Western Ontario Rm H417,268 Grosvenor St London ON Canada N6A 4V2
Citazione:
P.S. Puligandla et al., "Alveolar environment influences the metabolic and biophysical properties of exogenous surfactants", J APP PHYSL, 88(3), 2000, pp. 1061-1071

Abstract

Several factors have been shown to influence the efficacy of exogenous surfactant therapy in the acute respiratory distress syndrome. We investigatedthe effects of four different alveolar environments (control, saline-lavaged, N-nitroso-N-methylurethane, and hydrochloric acid) on the metabolic andfunctional properties of two exogenous surfactant preparations: bovine lipid extract surfactant and recombinant surfactant-associated protein (SP) C drug product (rSPC) administered to each of these groups. The main difference between these preparations was the lack of SP-B in the rSPC. Our resultsdemonstrated differences in the large aggregate Fool sizes recovered from each of the experimental groups. We also observed differences in SP-A content, surface area cycling characteristics, and biophysical activities of these large aggregate forms after the administration of the two exogenous surfactant preparations. We conclude that the alveolar environment plays a critical role, influencing the overall efficacy of exogenous surfactant therapy. Thus further preclinical studies are warranted to investigate the specific factors within the alveolar environment that lead to the differences observed in this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:44:49