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Titolo:
Angiotensin-converting enzyme ID polymorphism and fitness phenotype in theHERITAGE Family Study
Autore:
Rankinen, T; Perusse, L; Gagnon, J; Chagnon, YC; Leon, AS; Skinner, JS; Wilmore, JH; Rao, DC; Bouchard, C;
Indirizzi:
Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA Pennington Biomed ResCtr Baton Rouge LA USA 70808 on Rouge, LA 70808 USA Univ Laval, Phys Act Sci Lab, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 t Sci Lab, St Foy, PQ G1K 7P4, Canada Univ Minnesota, Sch Kinesiol & Leisure Studies, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 tudies, Minneapolis, MN 55455 USA Indiana Univ, Dept Kinesiol, Bloomington, IN USA Indiana Univ BloomingtonIN USA Univ, Dept Kinesiol, Bloomington, IN USA Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 nesiol, College Stn, TX 77843 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 88, anno: 2000,
pagine: 1029 - 1035
SICI:
8750-7587(200003)88:3<1029:AEIPAF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAXIMAL AEROBIC POWER; PHYSICAL-FITNESS; ACE LEVELS; GENE; PERFORMANCE; EXERCISE; TWINS; MEN; HYPERTENSION; RESEMBLANCE;
Keywords:
candidate gene; exercise training; responsiveness; insertion/deletion polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Bouchard, C Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA Pennington Biomed Res Ctr 6400 Perkins Rd Baton Rouge LA USA 70808
Citazione:
T. Rankinen et al., "Angiotensin-converting enzyme ID polymorphism and fitness phenotype in theHERITAGE Family Study", J APP PHYSL, 88(3), 2000, pp. 1029-1035

Abstract

It has been suggested that genetic variation in the angiotensin-convertingenzyme (ACE) gene is associated with physical performance. We studied the association between the ACE insertion (I)/deletion (D) polymorphism and several fitness phenotypes measured before and after 20 wk of a standardized endurance training program in sedentary Caucasian (n = 476) and black (n = 248) subjects. Phenotypes measured were oxygen uptake ((V) over dot O-2), work rate, heart rate, minute ventilation, tidal volume, and blood lactate levels during maximal and submaximal [50 W and at 60 and 80% of maximal (V) over dot O-2 ((V) over dot O-2max)] exercise and stroke volume and cardiac output during submaximal exercise (50 W and at 60% (V) over dot O-2max). TheACE ID polymorphism was typed with the three-primer PCR method. Out of 216association tests performed on 54 phenotypes in 4 groups of participants, only 11 showed significant (P values from 0.042 to 0.0001) associations with the ACE ID polymorphism. In contrast to previous claims, in Caucasian offspring, the DD homozygotes showed a 14-38% greater increase with training in (V) over dot O-2max, (V) over dot O-2 at 80% of (V) over dot O-2max and all work rate phenotypes and a 36% greater decrease in heart rate at 50 W than did the II homozygotes. No associations were evident in Caucasian parents or black parents or offspring. Thus these data do not support the hypothesis that the ACE ID polymorphism plays a major role in cardiorespiratory endurance.

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Documento generato il 26/09/20 alle ore 14:34:40