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Titolo:
Pulmonary vascular response of the coati to chronic hypoxia
Autore:
Hanson, WL; Boggs, DF; Kay, JM; Hofmeister, SE; Okada, O; Wagner, WW;
Indirizzi:
Indiana Univ, Sch Med, Dept Physiol & Biophys, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 iophys, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Anesthesia, Indianapolis, IN 46202 USA IndianaUniv Indianapolis IN USA 46202 thesia, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Pediat, Indianapolis, IN 46202 USA Univ Colorado, Hlth Sci Ctr, Cardiovasc Pulm Res Lab, Denver, CO 80262 USAUniv Colorado Denver CO USA 80262 vasc Pulm Res Lab, Denver, CO 80262 USA Eastern Washington Univ, Dept Biol, Cheney, WA 99004 USA Eastern Washington Univ Cheney WA USA 99004 pt Biol, Cheney, WA 99004 USA McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 4A6, Canada McMaster Univ Hamilton ON Canada L8N 4A6 ed, Hamilton, ON L8N 4A6, Canada Chiba Univ, Sch Med, Dept Chest Med, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Med, Dept Chest Med, Chiba 2608670, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 88, anno: 2000,
pagine: 981 - 986
SICI:
8750-7587(200003)88:3<981:PVROTC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLATERAL VENTILATION; HIGH-ALTITUDE; SMOOTH-MUSCLE; HYPERTENSION; RATS; CIRCULATION; RECOVERY; FEATURES; DISEASE; GROWTH;
Keywords:
collateral ventilation; species variation to hypoxia; pulmonary hypertension; high altitude; distal arterial muscularization; medial thickness; vascular smooth muscle; Nasua narica;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Wagner, WW Indiana Univ, Sch Med, Dept Physiol & Biophys, MS 374,635 Barnhill Dr, Indianapolis, IN 46202 USA Indiana Univ MS 374,635 Barnhill Dr Indianapolis IN USA 46202 A
Citazione:
W.L. Hanson et al., "Pulmonary vascular response of the coati to chronic hypoxia", J APP PHYSL, 88(3), 2000, pp. 981-986

Abstract

The unusually muscular pulmonary arteries normally present in cattle and swine residing at low altitude are associated with a rapid development of severe pulmonary hypertension when those animals are moved to high altitude. Because these species lack collateral ventilation, they appear to have an increased dependence on hypoxic vasoconstriction to maintain normal ventilation-perfusion balance, which, in turn, maintains thickened arterial walls. The only other species known to lack collateral ventilation is the coati, which, similarly, has thick-walled pulmonary arteries. We tested the hypothesis that coatis will develop severe high-altitude pulmonary hypertension byexposing six of these animals (Nasua narica) to a simulated altitude of 4,900 m for 6 wk. After the exposure, pulmonary arterial pressures were hardly elevated, right ventricular hypertrophy was minimal, there was no muscularization of pulmonary arterioles, and, most surprising of all, there was a decrease in medial thickness of muscular pulmonary arteries. These unexpected results break a consistent cross-species pattern in which animals with thick muscular pulmonary arteries at low altitude develop severe pulmonary hypertension at high altitude.

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Documento generato il 07/07/20 alle ore 19:57:19