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Titolo:
Viral dynamics during active cytomegalovirus infection and pathology
Autore:
Emery, VC;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Virol, London NW3 2QG, England Royal Free & Univ Coll Med Sch London England NW3 2QG n NW3 2QG, England
Titolo Testata:
INTERVIROLOGY
fascicolo: 5-6, volume: 42, anno: 1999,
pagine: 405 - 411
SICI:
0300-5526(199909/12)42:5-6<405:VDDACI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CMV DISEASE; HIV-1 INFECTION; AIDS PATIENTS; QUANTITY; PLASMA; VIRUS; RISK; LOAD; TRANSPLANTATION; SEROSTATUS;
Keywords:
PCR; quantitation; kinetics; diagnosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Emery, VC Royal Free & Univ Coll Med Sch, Dept Virol, Royal Free CAmpus,Rowland HillSt, London NW3 2QG, England Royal Free & Univ Coll Med Sch Royal Free CAmpus,Rowland Hill St London England NW3 2QG
Citazione:
V.C. Emery, "Viral dynamics during active cytomegalovirus infection and pathology", INTERVIROLO, 42(5-6), 1999, pp. 405-411

Abstract

The central role that cytomegalovirus (CMV) load plays in its pathogenesisis being unravelled, In AIDS patients with active CMV replication, many months prior to the development of CMV disease, elevated CMV load in the blood and urine are significantly associated with an increased risk of disease progression, In addition, elevated load in blood is associated with an increased risk of death. Intervention with ganciclovir acts to rapidly inhibit CMV replication in vivo and has allowed estimates of the clearance/replication rate of CMV to be performed. These data indicate that CMV replicates dynamically in the human host with a doubling time of approximately 1 day. This knowledge has been used to determine the relative contribution of initial viral load and rate of change of viral load as predictors of CMV disease in organ transplant recipients. The data show that both these parameters have prognostic value in multivariate models and should allow the developmentof novel patient management strategies, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 18:17:47