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Titolo:
Changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: state or trait marker status
Autore:
Plein, H; Berk, M;
Indirizzi:
Univ Witwatersrand, Sch Med, Dept Psychiat, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa Univ Witwatersrand, Sch Med, Dept Expt & Clin Pharmacol, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 15, anno: 2000,
pagine: 93 - 98
SICI:
0268-1315(200003)15:2<93:CITPIC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT2 RECEPTOR-BINDING; ANTIDEPRESSANT TREATMENTS; BLOOD-PLATELETS; UP-REGULATION; BRAIN; DRUGS; FENFLURAMINE; MECHANISM; PROLACTIN; NEURONS;
Keywords:
calcium; electroconvulsive therapy; peripheral marker; platelet; receptor; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univ Witwatersrand, Sch Med, Dept Psychiat, 7 York Rd, Johannesburg, SouthAfrica Univ Witwatersrand 7 York Rd Johannesburg South Africa uthAfrica
Citazione:
H. Plein e M. Berk, "Changes in the platelet intracellular calcium response to serotonin in patients with major depression treated with electroconvulsive therapy: state or trait marker status", INT CLIN PS, 15(2), 2000, pp. 93-98

Abstract

Platelet serotonin type 2A receptor (5-HT2A) sensitivity changes have previously been documented in depression, although it is unclear if this represents a stable trait marker of the illness, or whether it represents an acute state marker of depression that would change with treatment. Electroconvulsive therapy (ECT) may be a useful intervention to separate out trait and state marker status avoiding the potential confounding effects of pharmacotherapy on receptor function. Using spectrofluorometry, the platelet 5HT(2A), receptor sensitivity as reflected by the intracellular calcium response to serotonin stimulation, was measured every week in patients suffering frommajor depression and undergoing ECT. There was a significant drop in the platelet response to serotonin stimulation over a course of ECT, with an associated progressive decrease in Hamilton Rating Scale of Depression (HAM-D)scores. This may suggest either decreased sensitivity of platelet 5HT(2A) receptors as a mechanism of action of ECT, or changes in second messengers such as the inositide phospholipid system. This suggests that the enhanced sensitivity of platelet 5HT(2A) receptors may be a state marker of major depression. (C) 2000 Lippincott, Williams and Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 05:57:27