Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Blood dyscrasias in clozapine-treated patients in Italy
Autore:
Deliliers, GL;
Indirizzi:
Osped Maggiore, IRCCS, Dipartimento Sci Med, I-20122 Milan, Italy Osped Maggiore Milan Italy I-20122 timento Sci Med, I-20122 Milan, Italy Univ Milan, I-20122 Milan, Italy Univ Milan Milan Italy I-20122Univ Milan, I-20122 Milan, Italy
Titolo Testata:
HAEMATOLOGICA
fascicolo: 3, volume: 85, anno: 2000,
pagine: 233 - 237
SICI:
0390-6078(200003)85:3<233:BDICPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED AGRANULOCYTOSIS; NATIONAL REGISTRY; RISK-FACTORS; EOSINOPHILIA; NEUTROPENIA; SYSTEM;
Keywords:
clozapine; agranulocytosis; neutropenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Deliliers, GL Osped Maggiore, IRCCS, Dipartimento Sci Med, Via F Sforza 35, I-20122 Milan, Italy Osped Maggiore Via F Sforza 35 Milan Italy I-20122 n, Italy
Citazione:
G.L. Deliliers, "Blood dyscrasias in clozapine-treated patients in Italy", HAEMATOLOG, 85(3), 2000, pp. 233-237

Abstract

Background and Objectives. Clozapine is a dibenzodiazepine derivative thatis more effective than standard neuroleptic drugs In refractory schizophrenic patients, but its introduction in some countries was delayed by its propensity to cause blood dyscrasias. However, over the last ten years, different reports have clearly demonstrated that agranulocytosis and neutropenia can be easily prevented by means of strict hematologic surveillance. This article reviews the results of the first five years of the Italian ClozapineMonitoring System (ICLOS),Design and Methods. The hematologic parameters of 2,404 patients registered between 1995 and were collected in a central database, before patients began clozapine-treatment, weekly for first 18 weeks, and then monthly throughout the duration of therapy. On the basis of conventional criteria, different risk levels have been identified with total leukocyte <3,0x10(9)/L and/or an absolute neutrophil count <1.5x10(9)/L leading to immediate discontinuation of the drug. Results. The analysis shows that 0.9% of the patients developed neutropenia and 0,7% agranulocytosis mainly during the first 18 weeks of cloth pine treatment. Drug discontinuation led to the normalization of hematologic parameters in all cases, and the use of growth factors reduced the risk of infectious complications. Transient leukocytosis and eosinophilia were also observed but these did not have any serious clinical effects. Interpretation andConclusions. The ICLOS study confirms that regular hematologic monitoring Is highly effective in minimizing the incidence of clozapine-associated blood dyscrasias, The lower than initially expected rates of agranulocytosis and associated deaths are encouraging In view of the benefits of this drug in treatment-resistant schizophrenia and other neurologic disorders. (C) 2000 Ferrata Storti Foundation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:05:03