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Titolo:
Effect of amphetamine on extracellular acetylcholine and monoamine levels in subterritories of the rat medial prefrontal cortex
Autore:
Hedou, G; Homberg, J; Martin, S; Wirth, K; Feldon, J; Heidbreder, CA;
Indirizzi:
SmithKline Beecham Pharmaceut, Dept Neurosci Res, Neurobehav Res Grp, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England Swiss Fed Inst Technol, Lab Behav Biol, Zurich, Switzerland Swiss Fed InstTechnol Zurich Switzerland hav Biol, Zurich, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 390, anno: 2000,
pagine: 127 - 136
SICI:
0014-2999(20000225)390:1-2<127:EOAOEA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; NUCLEUS BASALIS-MAGNOCELLULARIS; CORTICAL PROJECTION PATTERNS; SPATIAL WORKING-MEMORY; FREELY MOVING RATS; CEREBRAL-CORTEX; FRONTAL-CORTEX; BEHAVIORAL SENSITIZATION; SEROTONERGIC PROJECTIONS; DOPAMINERGIC REGULATION;
Keywords:
acetylcholine; choline; cortex, medial prefrontal; norepinephrine; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Heidbreder, CA SmithKline Beecham Pharmaceut, Dept Neurosci Res, Neurobehav Res Grp, New Frontiers Sci Pk N,Bldg H25,Room 104A,3rd Ave, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut New Frontiers Sci Pk N,Bldg H25,Room 104A,3rd Ave Harlow Essex England CM19 5AW
Citazione:
G. Hedou et al., "Effect of amphetamine on extracellular acetylcholine and monoamine levels in subterritories of the rat medial prefrontal cortex", EUR J PHARM, 390(1-2), 2000, pp. 127-136

Abstract

The present study sought to investigate the contributions of the dorsal prelimbic/anterior cingulate and ventral prelimbic/infralimbic cortices to the reverse microdialysis of amphetamine (1, 10, 100, 500, and 1000 mu M) on dialysate acetylcholine, choline, norepinephrine, and serotonin levels. Theresults demonstrate that basal levels of acetylcholine, choline, and serotonin were homogeneous within subregions of the medial prefrontal cortex. Incontrast, dialysate norepinephrine levels were significantly higher in theanterior cingulate cortex compared with the infralimbic cortex. Reverse microdialysis of amphetamine in both subareas of the medial prefrontal cortexproduced a dose-dependent increase in norepinephrine and serotonin levels,the magnitude of this effect was similar in both subterritories of the medial prefrontal cortex. Microinfusion of amphetamine increased dialysate acetylcholine levels in a dose-dependent manner only in the infralimbic cortex. Finally, amphetamine decreased choline levels in both subregions of the medial prefrontal cortex. The magnitude of this effect was larger in the anterior cingulate cortex compared with its infralimbic counterpart. Since depletions of frontal cortical acetylcholine result in severe cognitive deficits, the present data raise the possibility that the type of neural integrative processes that acetylcholine mediates depends, at least in part, on thesubterritories that characterize the medial prefrontal cortex. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:08:55