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Titolo:
2B4 functions as a co-receptor in human NK cell activation
Autore:
Sivori, S; Parolini, S; Falco, M; Marcenaro, E; Biassoni, R; Bottino, C; Moretta, L; Moretta, A;
Indirizzi:
Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, ItalyUniv Genoa Genoa Italy I-16132 imentale, Sez Istol, I-16132 Genoa, Italy Univ Brescia, Dipartimento Sci Biomed & Biotecnol, Brescia, Italy Univ Brescia Brescia Italy mento Sci Biomed & Biotecnol, Brescia, Italy Ist Nazl Ric Canc, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 azl Ric Canc, I-16132 Genoa, Italy
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 30, anno: 2000,
pagine: 787 - 793
SICI:
0014-2980(200003)30:3<787:2FAACI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; CLASS-I MOLECULES; SURFACE-MOLECULE; T-CELLS; CLONING; IDENTIFICATION; CYTOTOXICITY; CD48;
Keywords:
NK cell; activating receptor; natural cytotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Moretta, A Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, Via GB Marsano 10, I-16132 Genoa, Italy Univ Genoa Via GB Marsano 10 Genoa Italy I-16132 Genoa, Italy
Citazione:
S. Sivori et al., "2B4 functions as a co-receptor in human NK cell activation", EUR J IMMUN, 30(3), 2000, pp. 787-793

Abstract

Natural cytotoxicity receptors (NKp46, NKp44 and NKp30) play a predominantrole in human NK cell triggering during natural cytotoxicity. Human 2B4 also induced NK cell activation in redirected killing assays using anti-2B4 monoclonal antibodies (mAb) and murine targets. Since this effect was confined to a fraction of NK cells, this suggested a functional heterogeneity of 2B4 molecules. Here we show that activation via 2B4 in redirected killing against murine targets is strictly dependent upon the engagement of NKp46 bymurine ligand (s) on target cells. Thus, NK cell clones expressing high surface density of NKp46 (NKp46(bright)) were triggered by anti-2B4 mAb, whereas NKp46(dull) clones were not although they expressed a comparable surface density of 2B4. mab-mediated modulation of NKp46 molecules in NKp46(bright) clones had no effect on the expression of 284 while it rendered cells unresponsive to anti-2B4 mAb. Finally, anti-2B4 mAb could induce NK cell triggering in NKp46(dull) clones provided that suboptimal doses of anti-NKp44 or anti-CD16 mAb were added to the redirected killing assay. These results indicate that differences in responses do not reflect a functional heterogeneity of 284 but rather depend on the co-engagement of triggering receptors.

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Documento generato il 19/09/20 alle ore 12:49:06