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Titolo:
TRAPP stably associates with the Golgi and is required for vesicle docking
Autore:
Barrowman, J; Sacher, M; Ferro-Novick, S;
Indirizzi:
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 Hughes Med Inst, New Haven, CT 06519 USA Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06519 USA Yale Univ NewHaven CT USA 06519 Dept Cell Biol, New Haven, CT 06519 USA
Titolo Testata:
EMBO JOURNAL
fascicolo: 5, volume: 19, anno: 2000,
pagine: 862 - 869
SICI:
0261-4189(20000301)19:5<862:TSAWTG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-PROTEIN; ENDOPLASMIC-RETICULUM; SACCHAROMYCES-CEREVISIAE; RETROGRADE TRANSPORT; VESICULAR TRANSPORT; SNARE COMPLEX; YEAST; ER; ENCODES; FUSION;
Keywords:
Bet3p; ER-Golgi transport; membrane traffic; TRAPP; vesicle docking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Ferro-Novick, S Yale Univ, Sch Med, Howard Hughes Med Inst, 333 Cedar St, New Haven, CT 06519 USA Yale Univ 333 Cedar St New Haven CT USA 06519 CT 06519 USA
Citazione:
J. Barrowman et al., "TRAPP stably associates with the Golgi and is required for vesicle docking", EMBO J, 19(5), 2000, pp. 862-869

Abstract

Bet3p, a component of a large novel complex called TRAPP, acts upstream ofendoplasmic reticulum (ER)Golgi SNAREs. Unlike the SNAREs, which reside onmultiple compartments, Bet3p is localized exclusively to Golgi membranes. While other proteins recycle from the Golgi to the ER, Bet3p and other TRAPP subunits remain associated with this membrane under conditions that blockanterograde traffic. We propose that the persistent localization of TRAPP to the Golgi may be important for its role in docking vesicles to this membrane. Consistent with this proposal, we find that transport vesicles fail to bind to Golgi membranes in vitro in the absence of Bet3p, Binding is restored by the addition of cytosol containing Bet3p, These findings indicate that TRAPP stably associates with the Golgi and is required for vesicle docking.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:45:35