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Titolo:
Changes in the metabolic elimination profile of testosterone following exposure of the crustacean Daphnia magna to tributyltin
Autore:
LeBlanc, GA; McLachlan, JB;
Indirizzi:
N Carolina State Univ, Dept Toxicol, Raleigh, NC 27695 USA N Carolina State Univ Raleigh NC USA 27695 Toxicol, Raleigh, NC 27695 USA
Titolo Testata:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
fascicolo: 3, volume: 45, anno: 2000,
pagine: 296 - 303
SICI:
0147-6513(200003)45:3<296:CITMEP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED IMPOSEX; NUCELLA-LAPILLUS; IN-VIVO; TOXICITY; MODULATION; HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: LeBlanc, GA N Carolina State Univ, Dept Toxicol, Raleigh, NC 27695 USA N Carolina State Univ Raleigh NC USA 27695 eigh, NC 27695 USA
Citazione:
G.A. LeBlanc e J.B. McLachlan, "Changes in the metabolic elimination profile of testosterone following exposure of the crustacean Daphnia magna to tributyltin", ECOTOX ENV, 45(3), 2000, pp. 296-303

Abstract

The biocide tributyltin has been found to cause the development of pseudohermaphroditic conditions in some neogastropod species, These abnormalities of the reproductive system have adversely affected the fecundity of some field populations of gastropods, resulting in local population declines. Current evidence suggests that tributyltin elicits these effects by interferingwith the biotransformation of testosterone to other steroid derivatives, resulting in an elevation in endogenous testosterone or some of its bioactive derivatives. The purpose of the present study was to determine whether tributyltin altered testosterone metabolism in daphnids (Daphnia magna), a species commonly used in ecotoxicology testing, Exposure of daphnids to 1.2 mu g (tin)/L caused a general increase in the rate of elimination of oxido-reduced, hydroxylated, and glucose-conjugated derivatives of testosterone, However, tributyltin exposure had no significant effect on the rate of elimination of the glucose-conjugated forms of the various oxide-reduced and hydroxylated derivatives of testosterone, As a result, the percentage of the oxide-reduced and hydroxylated metabolites of testosterone eliminated as glucose conjugates decreased with increasing tributyltin exposure levels. These results demonstrate that tributyltin causes alterations in testosterone metabolism in daphnids that mould result in an increase in the production ofoxide-reduced derivatives, These products are preferentially retained in the tissues of daphnids and are variously androgenic in vertebrates. The increased production of oxido-reduced derivatives of testosterone may be mechanically responsible for the masculinizing effects of tributyltin in some species and suggests that daphnids may be a suitable surrogate for evaluatingthe potential of chemicals to elicit this form of toxicity, (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 01:03:23