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Titolo:
Comparison of the effect of lipid A analog E5531 and the lipid a from Escherichia coli on phospholipid membrane properties
Autore:
Asai, Y; Watanabe, S;
Indirizzi:
Eisai & Co Ltd, Formulat Res Lab, Kawashima, Gifu 5016195, Japan Eisai & Co Ltd Kawashima Gifu Japan 5016195 awashima, Gifu 5016195, Japan Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3002635, Japan Eisai & Co Ltd Tsukuba Ibaraki Japan 3002635 kuba, Ibaraki 3002635, Japan
Titolo Testata:
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
fascicolo: 2, volume: 26, anno: 2000,
pagine: 199 - 204
SICI:
0363-9045(2000)26:2<199:COTEOL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERIAL-ENDOTOXIN; BINDING-PROTEIN; LIPOPOLYSACCHARIDE; ANTAGONIST;
Keywords:
fluidity; lipid A; phase transition temperature; phospholipid membrane; size;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Asai, Y Eisai & Co Ltd, Formulat Res Lab, Kawashima, Gifu 5016195, Japan Eisai & Co Ltd Kawashima Gifu Japan 5016195 , Gifu 5016195, Japan
Citazione:
Y. Asai e S. Watanabe, "Comparison of the effect of lipid A analog E5531 and the lipid a from Escherichia coli on phospholipid membrane properties", DRUG DEV IN, 26(2), 2000, pp. 199-204

Abstract

The effect of the lipid A analog E5531 on the phospholipid membrane was compared with that of the lipid A from Escherichia coli (EC). E5531 decreasedthe phase transition temperature of dipalmitoylphosphatidylcholine (DPPC) membrane and increased the fluidity and micropolarity. On the other hand, the effect of EC on the membrane was contradictory. These results suggested that the reason for the difference of biological effects of these two lipidA would be caused by the differences from the effect on the cell membranes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:39:01