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Titolo:
Mechanisms of nephrotoxicity from metal combinations: A review
Autore:
Madden, EF; Fowler, BA;
Indirizzi:
Univ Maryland, Toxicol Program, Baltimore, MD 21227 USA Univ Maryland Baltimore MD USA 21227 col Program, Baltimore, MD 21227 USA Univ Maryland, Toxicol Program, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 col Program, Baltimore, MD 21201 USA
Titolo Testata:
DRUG AND CHEMICAL TOXICOLOGY
fascicolo: 1, volume: 23, anno: 2000,
pagine: 1 - 12
SICI:
0148-0545(2000)23:1<1:MONFMC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEAD-BINDING-PROTEINS; CADMIUM-METALLOTHIONEIN; RAT; KIDNEY; AFFINITY; CELLS; GLUTATHIONE; PROTECTION; MORTALITY; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Madden, EF Univ Maryland, Toxicol Program, TEC-11 Bldg,5202 Westland Blvd,Baltimore,MD 21227 USA Univ Maryland TEC-11 Bldg,5202 Westland Blvd Baltimore MD USA 21227
Citazione:
E.F. Madden e B.A. Fowler, "Mechanisms of nephrotoxicity from metal combinations: A review", DRUG CHEM T, 23(1), 2000, pp. 1-12

Abstract

The common environmental pollutants arsenic, lead, and cadmium are each known to induce chronic renal disease and the molecular mechanisms of such toxic events are being clarified. Nephrotoxicity of these metals is due to the fact that urinary elimination is a main route of excretion, and the proximal tubules are especially sensitive due to their high reabsorptive activity. Renal pathological effects of these metals vary with the chemical form of the metal, the dose, and whether the exposure is acute or chronic in nature. The few isolated studies of combined metal exposures indicate that these pathological effects may be altered due to unknown interactions of these metals within the kidney. Biological factors within the cell such as metal binding proteins and inclusion bodies may also influence metal-metal interactions. Further research is needed to specify the parameters or criteria bywhich metal interactions is to be assessed for unique biological response patterns to aid in the risk assessment analysis of environmental and occupational metal exposures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:39:36