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Titolo:
Sequential programs of retinoic acid synthesis in the myocardial and epicardial layers of the developing avian heart
Autore:
Xavier-Neto, J; Shapiro, MD; Houghton, L; Rosenthal, N;
Indirizzi:
Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA 02129 USA Massachusetts Gen Hosp Charlestown MA USA 02129 Charlestown, MA 02129 USA Univ Sao Paulo, Fac Med, Inst Coracao, Lab Genet & Cardiol Mol, BR-05040300 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05040300 BC05040300 Sao Paulo, Brazil Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 omparat Zool, Cambridge, MA 02138 USA Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 tionary Biol, Cambridge, MA 02138 USA Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Neurobiol, Boston, MA 02115 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 1, volume: 219, anno: 2000,
pagine: 129 - 141
SICI:
0012-1606(20000301)219:1<129:SPORAS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOMYOSIN EXPRESSION PATTERNS; CHAMBER-SPECIFIC EXPRESSION; RXR-ALPHA; CHICKEN HEART; QUAIL EMBRYO; IMMUNOHISTOCHEMICAL ANALYSIS; CARDIAC MORPHOGENESIS; GENE; ELEMENT; MUSCLE;
Keywords:
atria; ventricles; retinoic acid; RALDH2; epicardium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenthal, N Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA 02129 USA Massachusetts Gen Hosp Charlestown MA USA 02129 MA 02129 USA
Citazione:
J. Xavier-Neto et al., "Sequential programs of retinoic acid synthesis in the myocardial and epicardial layers of the developing avian heart", DEVELOP BIO, 219(1), 2000, pp. 129-141

Abstract

Endogenous patterns of retinoic acid (RA) signaling in avian cardiac morphogenesis were characterized by localized expression of a key RA-synthetic enzyme, RALDH2, which displayed a biphasic pattern during heart development. RALDH2 immunoreactivity was initially apparent posterior to Hensen's node of stage 5-6 embryos and subsequently in somites and unsegmented paraxial and lateral plate mesoderm overlapping atrial precursors in the cardiogenic plate of stage 9- embryos. Initial RALDH2 synthesis in the posterior myocardium coincided with activation of the AMHC1 gene, a RA-responsive marker ofinflow heart segments. A wave of RALDH2 synthesis then swept the myocardium in a posterior-to-anterior direction, reaching the outflow tract by stage13, then fading from the myocardial layer. The second phase of RALDH2 expression, initiated at stage 18 in the proepicardial organ, persisted in mi,oratory epicardial cells that completely enveloped the heart by stage 24. Early restriction of RALDH2 expression to the posterior cardiogenic plate, overlapping RA-inducible gene activation, provides evidence for commitment ofposterior avian heart segments by localized production of RA, whereas subsequent RALDH2 expression exclusively in the migratory epicardium suggests arole for the morphogen in ventricular expansion and morphogenesis of underlying myocardial tissues. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 04:54:06