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Titolo:
A solution-phase combinatorial synthesis of selective dopamine D-4 ligands
Autore:
Williams, JP; Lavrador, K;
Indirizzi:
CombiChem Inc, Dept Med Chem, San Diego, CA 92121 USA CombiChem Inc San Diego CA USA 92121 pt Med Chem, San Diego, CA 92121 USA
Titolo Testata:
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
fascicolo: 1, volume: 3, anno: 2000,
pagine: 43 - 50
SICI:
1386-2073(200002)3:1<43:ASCSOS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENTARY MOLECULAR REACTIVITY; UGI 4-COMPONENT CONDENSATION; OLEFIN METATHESIS REACTION; SMALL ORGANIC-MOLECULES; PARALLEL SYNTHESIS; FLUOROUS SYNTHESIS; COMPOUND LIBRARIES; CONVERTIBLE ISOCYANIDE; CHEMICAL LIBRARIES; D4 RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, JP Neurocrine Biosci Inc, Dept Med Chem, 10555 Sci Ctr Dr, San Diego, CA 92121 USA Neurocrine Biosci Inc 10555 Sci Ctr Dr San Diego CA USA 92121
Citazione:
J.P. Williams e K. Lavrador, "A solution-phase combinatorial synthesis of selective dopamine D-4 ligands", COMB CHEM H, 3(1), 2000, pp. 43-50

Abstract

Utilizing combinatorial synthesis and a preparative LC-MS automated chromatography system we have prepared and purified a library of 4-[2-(1,2,4-oxadiazolyl]piperidines that were designed to be novel and selective dopamine D-4 ligands. In one round of synthesis we identified N-4-chlorobenzyl-4-[2-(3-(2-thienyl)-1,2,4-oxadiazolyl)]piperidine with a K-d of 5 nM for the human D-4 receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:03:42