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Titolo:
Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction
Autore:
Al Suwaidi, J; Hamasaki, S; Higano, ST; Nishimura, RA; Holmes, DR; Lerman, A;
Indirizzi:
Mayo Clin & Mayo Fdn, Ctr Coronary Physiol & Imaging, Div Cardiovasc Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Dis, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA Mayo Clin& Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA
Titolo Testata:
CIRCULATION
fascicolo: 9, volume: 101, anno: 2000,
pagine: 948 - 954
SICI:
0009-7322(20000307)101:9<948:LFOPWM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACORONARY ULTRASOUND; DEPENDENT VASODILATION; RESISTANCE VESSELS; FLOW VELOCITY; HEART-DISEASE; RISK-FACTORS; L-ARGININE; ACETYLCHOLINE; HUMANS; ATHEROSCLEROSIS;
Keywords:
atherosclerosis; acetylcholine; endothelium; coronary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lerman, A Mayo Clin, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin 200 1st St SW Rochester MN USA 55905 ter, MN 55905 USA
Citazione:
J. Al Suwaidi et al., "Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction", CIRCULATION, 101(9), 2000, pp. 948-954

Abstract

Background-Coronary endothelial dysfunction is characterized by vasoconstrictive response to the endothelium-dependent vasodilator acetylcholine. Although endothelial dysfunction is considered an early phase of coronary atherosclerosis, there is a paucity of information regarding the outcome of these patients. Thus, this study was designed to evaluate the outcome of patients with mild coronary artery disease on the basis of their endothelial function. Methods and Results-Follow-up was obtained in 157 patients with mildly diseased coronary arteries who had undergone coronary vascular reactivity evaluation by graded administration of intracoronary acetylcholine, adenosine, and nitroglycerin and intracoronary ultrasound at the time of diagnostic study. Patients were divided on the basis of their response to acetylcholine into 3 groups: group 1 (n = 83), patients with normal endothelial function;group 2 (n = 32), patients with mild endothelial dysfunction; and group 3 (n = 42), patients with severe endothelial dysfunction. Over an average 28-month follow-up (range, 11 to 52 months), none of the patients from group 1or 2 had cardiac events. However, 6 (14%) with severe endothelial dysfunction had 10 cardiac events (P<0.05 versus groups 1 and 2). Cardiac events included myocardial infarction, percutaneous or surgical coronary revascularization, and/or cardiac death. Conclusions-Severe endothelial dysfunction in the absence of obstructive coronary artery disease is associated with increased cardiac events. This study supports the concept that coronary endothelial dysfunction may play a role in the progression of coronary atherosclerosis.

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Documento generato il 07/07/20 alle ore 05:17:45