Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RAFTK/Pyk2-mediated cellular signalling
Autore:
Avraham, H; Park, SY; Schinkmann, K; Avraham, S;
Indirizzi:
Beth Israel Deaconess Med Ctr, Harvard Inst Med, Div Expt Med & Hematol Oncol, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr Boston MA USA 02115 l, Boston, MA 02115 USA
Titolo Testata:
CELLULAR SIGNALLING
fascicolo: 3, volume: 12, anno: 2000,
pagine: 123 - 133
SICI:
0898-6568(200003)12:3<123:RCS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; PROTEIN-TYROSINE KINASE; GTPASE-ACTIVATING PROTEIN; VASCULAR SMOOTH-MUSCLE; LIVER EPITHELIAL-CELLS; N-TERMINAL KINASE; ACTIN CYTOSKELETON; KAPOSIS-SARCOMA; ANGIOTENSIN-II; GROWTH-FACTOR;
Keywords:
tyrosine kinases; RAFTK/Pyk2; FAK; signalling;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Avraham, S Beth Israel Deaconess Med Ctr, Harvard Inst Med, Div Expt Med &Hematol Oncol, 4 Blackfan Circle, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr 4 Blackfan Circle Boston MA USA 02115
Citazione:
H. Avraham et al., "RAFTK/Pyk2-mediated cellular signalling", CELL SIGNAL, 12(3), 2000, pp. 123-133

Abstract

Intracellular signal transduction following extracellular ligation by a wide variety of surface molecules involves the activation and tyrosine phosphorylation of protein tyrosine kinases (PTKs). Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and tyrosine kinases, is a critical regulatory mechanism for various physiological processes, including cell growth, differentiation, metabolism, cellcycle regulation and cytoskeleton function. The focal adhesion PTK family consists of the focal adhesion kinase (FAK) and the RAFTK/Pyk2 kinase (alsoknown as CAK-beta and CADTK). RAFTK/Pyk2 can be activated by a variety of extracellular signals that elevate intracellular calcium concentration, andby stress signals. RAFTK/Pyk2 is expressed mainly in the central nervous system and in cells derived from hematopoietic lineages, while FAK is widelyexpressed in various tissues and links transmembrane integrin receptors tointracellular pathways. This review describes the role of RAFTK/Pyk2 in Various signalling cascades and details the differential signalling by FAK and RAFTK/Pyk2. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:17:12