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Titolo:
Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum
Autore:
Rodriguez-Martinez, E; Camacho, A; Maldonado, PD; Pedraza-Chaverri, J; Santamaria, D; Galvan-Arzate, S; Santamaria, A;
Indirizzi:
SSA, Natl Inst Neurol & Neurosurg Manuel Velasco Suare, Dept Neurochem, Mexico City 14269, DF, Mexico SSA Mexico City DF Mexico 14269 Neurochem, Mexico City 14269, DF, Mexico Natl Autonomous Univ Mexico, Fac Chem, Mexico City 04510, DF, Mexico Natl Autonomous Univ Mexico Mexico City DF Mexico 04510 04510, DF, Mexico SSA, Natl Inst Pediat, Neurochem Lab, Mexico City 14269, DF, Mexico SSA Mexico City DF Mexico 14269 rochem Lab, Mexico City 14269, DF, Mexico
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 858, anno: 2000,
pagine: 436 - 439
SICI:
0006-8993(20000310)858:2<436:EOQAOE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; BRAIN; GLUTATHIONE; TISSUE; ASSAY;
Keywords:
quinolinic acid; superoxide dismutase; glutathione; glutathione peroxidase; corpus striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Santamaria, A SSA, Natl Inst Neurol & Neurosurg Manuel Velasco Suare, DeptNeurochem, AvInsurgentes Sur 3877, Mexico City 14269, DF, Mexico SSA Av Insurgentes Sur 3877 Mexico City DF Mexico 14269 xico
Citazione:
E. Rodriguez-Martinez et al., "Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum", BRAIN RES, 858(2), 2000, pp. 436-439

Abstract

The response of endogenous antioxidants to the N-methyl-D-aspartate (NMDA)receptor agonist and excitotoxin, quinolinic acid (QUIN), was investigatedin rat corpus striatum. Animals treated with QUIN (240 nmol/mu l), were sacrificed at 120 min after a single intrastriatal injection to examine the alterations in the levels of both reduced (GSH) and oxidized (GSSG) glutathione, and the activities of the antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (Gpx). Changes in the rate of lipid peroxidation (LP) were also measured after exposure to different doses of QUIN (60,120, 240 and 480 nmol/mu l) as an index of oxidative stress. When comparedto control, Lipid peroxidation was increased at QUIN doses of 240 and 480 nmol/mu l. Striatal levels of GSH and GSSG were decreased and increased, respectively, after QUIN injection; whereas GPx activity was unchanged. Cytosolic copper/zinc SOD (CuZn-SOD) activity decreased after treatment, while mitochondrial manganese SOD (Mn-SOD) was unchanged. The alterations observedon these antioxidant systems suggest that QUIN toxicity is mediated by specific mechanisms leading to oxidative stress. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:22:11