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Titolo:
The neural correlates of 'deaf-hearing' in man - Conscious sensory awareness enabled by attentional modulation
Autore:
Engelien, A; Huber, W; Silbersweig, D; Stern, E; Frith, CD; Doring, W; Thron, A; Frackowiak, RSJ;
Indirizzi:
Aachen Tech Univ, Aachen, Germany Aachen Tech Univ Aachen GermanyAachen Tech Univ, Aachen, Germany Wellcome Dept Cognit Neurol, London, England Wellcome Dept Cognit Neurol London England gnit Neurol, London, England Cornell Univ, Med Ctr, New York Hosp, Dept Psychiat,Funct Neuroimaging Lab, New York, NY 10021 USA Cornell Univ New York NY USA 10021 uroimaging Lab, New York, NY 10021 USA
Titolo Testata:
BRAIN
, volume: 123, anno: 2000,
parte:, 3
pagine: 532 - 545
SICI:
0006-8950(200003)123:<532:TNCO'I>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PURE WORD DEAFNESS; PRIMARY AUDITORY-CORTEX; TEMPORAL-LOBE LESIONS; PREFRONTAL CORTEX; WORKING-MEMORY; PARKINSONS-DISEASE; CORTICAL DEAFNESS; BASAL GANGLIA; FUNCTIONAL-ANATOMY;
Keywords:
cortical deafness; auditory physiology; functional neuroimaging; attention;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Engelien, A Cornell Univ, Coll Med, Funct Neuroimaging Lab, 525 E 68th St,Box 140, NewYork, NY 10021 USA Cornell Univ 525 E 68th St,Box 140 New York NY USA 10021 1 USA
Citazione:
A. Engelien et al., "The neural correlates of 'deaf-hearing' in man - Conscious sensory awareness enabled by attentional modulation", BRAIN, 123, 2000, pp. 532-545

Abstract

Attentional modulation of normal sensory processing has a two-fold impact on human brain activity: activation of a network of localized brain regionsis associated with paying attention, and activation of specific sensory regions is enhanced relative to passive stimulation. The mechanisms underlying attentional modulation of perception in patients with lesions of sensory cortices are less well understood, Here we report a unique patient suffering from extensive bilateral destruction of the auditory cortices (including the primary auditory fields) who demonstrated conscious perception of the onset and offset of sounds only when selectively attending to the auditory modality. This is the first description of such an attentively modulated 'deaf-hearing' phenomenon and its neural correlates, using (H2O)-O-15-PET, Increases in cerebral blood flow associated with conscious awareness of sound that was achieved by listening attentively (compared with identical auditory stimulation presented when the patient was inattentive) were found bilaterally in the lateral (pre)frontal cortices, the spared middle temporal cortices and the cerebellar hemispheres. We conclude that conscious awareness of sounds may be achieved in the absence of the primary auditory cortex, andthat selective, 'top-down' attention, associated with prefrontal systems, exerts a crucial modulatory effect on auditory perception within the remaining auditory system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:38:32