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Titolo:
IV glycine and oral D-cycloserine effects on plasma and CSF amino acids inhealthy humans
Autore:
DSouza, DC; Gil, R; Cassello, K; Morrissey, K; Abi-Saab, D; White, J; Sturwold, R; Bennett, A; Karper, LP; Zuzarte, E; Charney, DS; Krystal, JH;
Indirizzi:
W Haven Vet Affairs Med Ctr, Schizophrenia Biol Res Ctr, W Haven, CT USA WHaven Vet Affairs Med Ctr W Haven CT USA Biol Res Ctr, W Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 47, anno: 2000,
pagine: 450 - 462
SICI:
0006-3223(20000301)47:5<450:IGAODE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; PREPULSE INHIBITION; NMDA RECEPTOR; D-SERINE; CEREBROSPINAL-FLUID; NEGATIVE SYMPTOMS; INDUCED DEFICITS; MODULATORY SITE; XENOPUS OOCYTES; PARTIAL AGONIST;
Keywords:
glycine; D-cycloserine; strychnine-insensitive; NMDA receptors; cerebrospinal fluid; amino acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: D'Souza, DC VA Connecticut Healthcare Syst, Psychiat Serv, 116A,950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst 116A,950 Campbell Ave W Haven CT USA 06516
Citazione:
D.C. D'Souza et al., "IV glycine and oral D-cycloserine effects on plasma and CSF amino acids inhealthy humans", BIOL PSYCHI, 47(5), 2000, pp. 450-462

Abstract

Background: The amino acid glycine, modulates neuro-transmission via actions at GLY-A receptor and GLY-B receptor. The latter are coagonist sites associated with N-Methyl-D-Aspartate (NMDA) glutamate receptors, The central bioavailability of peripherally administered glycine has not Been adequatelycharacterized in humans. Methods: Healthy human subjects were administered either oral D-cycloserine (50 mg or placebo) and intravenous glycine (saline, 100 mg/kg or 200 mg/kg) in random order over 4 test days under double-blind conditions. Cerebrospinal fluid was collected by lumbar puncture performed on the first test day was analyzed to determine amino acid levels. The acoustic startle response was measured on the second test day,Results: intravenous glycine dose-dependently increased both serum and CSFglycine and serine levels. Neither glycine nor DCS produced any significant effects on behavior, cognition or the acoustic startle response. Neither IV glycine nor DCS were associated with arty toxicity,Conclusions: Thus, peripheral glycine administration raised CSF glycine levels without producing any clear central nervous system effects. Glycine and D-cycloserine did not,worsen cognitive test performance and did not induce Behavioral symptoms on their own. The possibility that glycine and D-cycloserine enhanced cognitive test performance cannot be excluded given the psychometric limitations of the test battery.. (C) 2000 Society of BiologicalPsychiatry.

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Documento generato il 18/01/20 alle ore 13:11:06