Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages
Autore:
Mori, H; Arai, T; Hirota, K; Ishii, H; Endo, N; Makino, K; Fukuda, K;
Indirizzi:
Kyoto Univ Hosp, Dept Anesthesia, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Hosp Kyoto Japan 6068507 esia, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Inst Adv Energy, Uji, Kyoto 6110011, Japan Kyoto Univ Uji Kyoto Japan 6110011 Adv Energy, Uji, Kyoto 6110011, Japan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
fascicolo: 1, volume: 1474, anno: 2000,
pagine: 93 - 99
SICI:
0304-4165(20000306)1474:1<93:EO6AXO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR KAPPA-B; GLOBAL BRAIN ISCHEMIA; TERT-BUTYL-NITRONE; TRANSCRIPTION FACTOR; CELLS; TETRAHYDROBIOPTERIN; PTERIN-6-ALDEHYDE; GENERATION; INDUCTION; COFACTOR;
Keywords:
6-formylpterin; inducible nitric oxide synthase; nitric oxide; spin trap; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, T Kyoto Univ Hosp, Dept Anesthesia, Sakyo Ku, 54 Kawahara Cho,Shogoin, Kyoto6068507, Japan Kyoto Univ Hosp 54 Kawahara Cho,Shogoin Kyoto Japan6068507 Japan
Citazione:
H. Mori et al., "Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages", BBA-GEN SUB, 1474(1), 2000, pp. 93-99

Abstract

As well as superoxide generated from neutrophils, nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in macrophages plays an important role in inflammation, We previously showed that 6-formylpterin, a xanthine oxidase inhibitor, has a superoxide scavenging activity. In the presentstudy, to elucidate other pharmacological activities of 6-formylpterin, weinvestigated the effects of 6-formylpterin on production of nitric oxide (NO) in the murine macrophage cell line RAW 264.7 stimulated by lipopolysaccharide (LPS) and interferon-gamma (INF-gamma). 6-Formylpterin suppressed the expression of iNOS, and it also inhibited the catalytic activity of iNOS,which collectively resulted in the inhibition of NO production in the stimulated macrophages. However, 6-formylpterin did not scavenge the released NO from an NO donor, S-nitroso-N-acetylpenicillamine (SNAP). These results indicate that 6-formylpterin inhibits pathological NO generation from macrophages during inflammation, but that it does not disturb the physiological action of NO released from other sources. (C) 2000 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:11:08